SEARCHCOHORTobstetrics and gynecology, pediatrics

cohort·obstetrics and gynecology, pediatrics, nutrition, epidemiology, public health·PMC10255277

Cohort profile: the BABY1000 pilot prospective longitudinal birth cohort study based in Sydney, Australia

BMJ Open · 14 authors, 5 centres

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TL;DR

This paper describes the design and initial findings of the BABY1000 pilot birth cohort study, which aimed to recruit 250 women in Sydney at preconception or early pregnancy to study factors affecting long-term health.

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The BABY1000 study is a pilot prospective longitudinal birth cohort based in Sydney, Australia. It aimed to recruit women at preconception or ≤12 weeks' gestation to identify factors before, during, and after pregnancy that impact longer-term health, and to assess study feasibility. Biosamples and clinical measurements were also collected. Key early findings reported include participant demographics and dietary adequacy during pregnancy. Analyses are ongoing for infant feeding, growth, microbiome relationships, and the pandemic's impact on families. Limitations include reduced sample size and data completeness due to pandemic-related restrictions.

STUDY TYPE

cohort

SPECIALTY

obstetrics and gynecology

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AI pipeline

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ORIGINAL PAPER

PMC10255277

Cohort profile: the BABY1000 pilot prospective longitudinal birth cohort study based in Sydney, Australia

BMJ Open

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ABSTRACT

Purpose The health of parents prior to conception, a woman’s health during pregnancy and the infant’s environment across their first months and years collectively have profound effects on the child’s health across the lifespan. Since there are very few cohort studies in early pregnancy, gaps remain in our understanding of the mechanisms underpinning these relationships, and how health may be optimised. ‘BABY1000’, a pilot prospective longitudinal birth cohort study, aims to (1) identify factors before and during pregnancy and early life that impact longer-term health and (2) assess the feasibility and acceptability of study design to inform future research. Participants Participants were based in Sydney, Australia. Women were recruited at preconception or 12 weeks’ gestation, and data were collected from them throughout pregnancy and postpartum, their children until the age of 2 years, and dietary information from a partner (if able) at the last study visit. The pilot aimed to recruit 250 women. However, recruitment ceased earlier than planned secondary to limitations from the COVID-19 pandemic and the final number of subjects was 225. Findings to date Biosamples, clinical measurements and sociodemographic/psychosocial measures were collected using validated tools and questionnaires. Data analysis and 24-month follow-up assessments for children are ongoing. Key early findings presented include participant demographics and dietary adequacy during pregnancy. The COVID-19 pandemic and associated public health and research restrictions affected recruitment of participants, follow-up assessments and data completeness. Future plans The BABY1000 study will provide further insight into the developmental origins of health and disease and inform design and implementation of future cohort and intervention studies in the field. Since the BABY1000 pilot was conducted across the COVID-19 pandemic, it also provides unique insight into the early impacts of the pandemic on families, which may have effects on health across the lifespan.

CITATION EXPORT

Allison Marie Grech, Nathalie Kizirian, Ravin Lal et al.. Cohort profile: the BABY1000 pilot prospective longitudinal birth cohort study based in Sydney, Australia. BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2022-068275

AUTHORS

14 · 5 CENTRES

Allison Marie Grech, Nathalie Kizirian, Ravin Lal, Angelika Zankl, Karin Birkner, Reeja Nasir, Roslyn Muirhead, Rachelle Sau-Harvey, Marjan Mosalman Haghighi, Clare Collins, Andrew Holmes, Michael Skilton, Stephen Simpson, Adrienne Gordon

1Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, New South Wales, Australia
2The University of Sydney Charles Perkins Centre, Sydney, New South Wales, Australia
3The University of Newcastle, Callaghan, New South Wales, Australia
4Hunter Medical Research Institute, The University of Newcastle, New Lambton, New South Wales, Australia
5Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia