Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research

BMJ Open · 7 authors, 4 centres

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TL;DR

The cohort is designed for longitudinal research into the genetic and environmental determinants of mental health.

Full summary

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The SHARE-MH cohort was established to address gaps in data for mental health research by linking survey responses, electronic health records, and genetic data. Participants provided consent for linkage of their survey data with health records and genetic data from spare blood samples. Demographic analysis shows the cohort is predominantly female, middle-aged, heterosexual, and from less deprived areas. A key strength is the unique combination of data sources for triangulation, including detailed self-reported mental health, genetic data, and clinical records. Limitations include potential over-representation of individuals with mental ill health and those interacting with healthcare services, as over 40% self-reported a mental health diagnosis and around 50% had been dispensed an antidepressant. The cohort is intended to drive research in psychiatric genetics and mental-physical comorbidity.

STUDY TYPE

cohort

SPECIALTY

psychiatry

SUMMARISED BY

AI pipeline

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ORIGINAL PAPER

PMC10806588

Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research

BMJ Open

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ABSTRACT

Abstract Purpose The SHARE Mental Health (SHARE-MH) cohort was established to address the paucity of clinical and genetic data available for mental health research. The cohort brings together detailed mental health questionnaire responses, routinely collected electronic health data and genetic data to provide researchers with an unprecedented linkable dataset. This combination of data sources allows researchers to track mental health longitudinally, across multiple settings. It will be of interest to researchers investigating the genetic and environmental determinants of mental health, the experiences of those interacting with healthcare services, and the overlap between self-reported and clinically derived mental health outcomes. Participants The cohort consists of individuals sampled from the Scottish Health Research Register (SHARE). To register for SHARE, individuals had to be over the age of 16 years and living in Scotland. Cohort participants were recruited by email and invited to take part in an online mental health survey. When signing up for SHARE, participants also provided written consent to the use of their electronic health records and genetic data—derived from spare blood samples—for research purposes. Findings to date From 5 February 2021 to 27 November 2021, 9829 individuals completed a survey of various mental health topics, capturing information on symptoms, diagnoses, impact and treatment. Survey responses have been made linkable to electronic health records and genetic data using a single patient identifier. Linked data have been used to describe the cohort in terms of their demographics, self-reported mental health, inpatient and outpatient hospitalisations and dispensed prescriptions. Future plans The cohort will be improved through linkage to a broader variety of routinely collected data and to increasing amounts of genetic data obtained through blood sample diversion. We see the SHARE-MH cohort being used to drive forward novel areas of mental health research and to contribute to global efforts in psychiatric genetics. Keywords: MENTAL HEALTH, EPIDEMIOLOGY, GENETICS, Surveys and Questionnaires

CITATION EXPORT

Matthew Henry Iveson, Emily L Ball, Jason Doherty et al.. Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research. BMJ Open. (2024). https://doi.org/10.1136/bmjopen-2023-078246

AUTHORS

7 · 4 CENTRES

Matthew Henry Iveson, Emily L Ball, Jason Doherty, Carys Pugh, Shobna Vashishta, Colin N A Palmer, Andrew McIntosh

1Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
2Department of Neurology, Washington University, St Louis, Missouri, USA
3Advanced Care Research Centre, The University of Edinburgh, Edinburgh, UK
4Division of Population Health and Genomics, University of Dundee, Dundee, UK