SEARCHCOHORTnephrology, cardiology

cohort·nephrology, cardiology, nutrition, clinical nutrition, internal medicine·PMC10310003

Combined evaluation of Geriatric nutritional risk index and Neutrophil to lymphocyte ratio for predicting all-cause and cardiovascular mortality in hemodialysis patients

PLOS ONE · 11 authors, 4 centres

AI SUMMARY

FIDELITY 100%

POPULATION240 maintenance hemodialysis patients aged 26–96 years from two hemodialysis centers in Nanjing

INTERVENTIONCombined assessment of GNRI and NLR for mortality prediction

COMPARISONFour groups based on GNRI (cut-off 89.01) and NLR (cut-off 4): high GNRI + high NLR, high GNRI + low NLR, low GNRI + high NLR, low GNRI + low NLR

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This retrospective cohort study of 240 maintenance hemodialysis patients found that both Geriatric Nutritional Risk Index (GNRI) and Neutrophil-to-Lymphocyte Ratio (NLR) are independent risk factors for all-cause and cardiovascular mortality. Combining low GNRI with high NLR identified the group with the worst survival outcomes.

Full summary

822 CHARS

This retrospective cohort study enrolled 240 maintenance hemodialysis patients from two Nanjing hemodialysis centers between January 2014 and December 2017. Patients were grouped by cut-off values of GNRI (89.01) and NLR (4) into four combinations. During an average follow-up of 58 months, all-cause mortality was 20.83% (50/240) and cardiovascular mortality was 12.08% (29/240). Multifactorial Cox regression analysis identified both NLR and GNRI as independent risk factors for prognosis. Patients with low GNRI and high NLR (G3) had the worst all-cause and cardiovascular mortality, while the high GNRI plus low NLR group (G2) had the best all-cause survival. Limitations include the retrospective design, potential temporal changes in GNRI and NLR not accounted for, unmeasured confounders, and the small sample size.

PICO

PPOPULATION

240 maintenance hemodialysis patients aged 26–96 years from two hemodialysis centers in Nanjing

IINTERVENTION

Combined assessment of GNRI and NLR for mortality prediction

OOUTCOME

All-cause mortality and cardiovascular mortality

STUDY TYPE

cohort

SPECIALTY

nephrology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10310003

Combined evaluation of Geriatric nutritional risk index and Neutrophil to lymphocyte ratio for predicting all-cause and cardiovascular mortality in hemodialysis patients

PLOS ONE

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ABSTRACT

Abstract Objective Malnutrition, accompanied by an inflammatory profile, is a risk factor for poor prognosis in hemodialysis patients. The purpose of this study was to investigate the predictive value of NLR combined with GNRI for all-cause and cardiovascular mortality in hemodialysis patients. Methods A total of 240 maintenance hemodialysis (MHD) patients in hemodialysis centers were enrolled in this retrospective study. The influencing factors of all-cause death in hemodialysis patients were analyzed by COX regression. The cut-off values of GNRI and NLR for predicting mortality in enrolled MHD patients were 89.01 and 4, respectively. Based on these cut-off values, the patients were divided into four groups: G1: high GNRI (≥ 89.01) + high NLR (≥ 4) group; G2: high GNRI (≥ 89.01) + low NLR (<4) group, G3: low GNRI (< 89.01) + high NLR (≥4) group; G4: low GNRI (< 89.01) + low NLR (<4). Results During the follow-up period (average: 58 months), the all-cause mortality was 20.83%(50/240) and the cardiovascular mortality was 12.08%(29/240). Both NLR and GNRI were independent risk factors for the prognosis of MHD patients (P<0.05). Survival analysis showed that patients with low GNRI had a lower survival rate than those with high GNRI, whereas patients with high NLR had a lower survival rate than those with low NLR. Kaplan-Meier curve for all-cause mortality revealed that compared to G1, G2, and G4, G3 had the lowest survival rate, while G2 had the highest survival rate among all groups (P < 0.05). Kaplan-Meier curve for cardiovascular mortality showed that G3 had lower survival than G1, G2, and G4 (P < 0.001). Conclusions Our study demonstrates that bothGNRI and NLR are associated with all-cause mortality and cardiovascular mortality in MHD patients. Combining these two factorsmay contribute to a prognostic evaluation for MHD patients.

CITATION EXPORT

Jun Wang, Li-juan Huang, Bei Li et al.. Combined evaluation of Geriatric nutritional risk index and Neutrophil to lymphocyte ratio for predicting all-cause and cardiovascular mortality in hemodialysis patients. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0287696

AUTHORS

11 · 4 CENTRES

Jun Wang, Li-juan Huang, Bei Li, Mei-chang Xu, Lei Yang, Xu Deng, Xin Li, Gulali Aktas, Gulali Aktas, Gulali Aktas, Gulali Aktas

1Department of Nephrology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, 210014, Jiangsu Province, China
2Department of Nephrology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210012, Jiangsu Province, China
3Department of Science & Education Division, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Nanjing, 210014, Jiangsu Province, China
4Bolu Abant İzzet Baysal University: Bolu Abant Izzet Baysal Universitesi, TURKEY