International Journal of Molecular Sciences · 9 authors, 7 centres
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This case-control study found that a specific variant in the MTHFD1 gene was associated with increased risk of gynecologic cancer, while a variant in the MTHFR gene was associated with depression in healthy controls but not in cancer patients.
A case-control study of 200 women with gynecologic cancers and 240 healthy controls investigated genetic variants in one-carbon metabolism (MTHFR, MTR, MTHFD1) and their link to cancer risk and depression. Depression, assessed by the Hamilton Depression Scale, was significantly more frequent in cancer patients (69.5%) than controls (34.2%). The MTHFD1 rs2236225 variant was associated with an increased risk of gynecologic cancers. An association between depression and MTHFR rs1801133 was found in controls but not in cancer patients. Limitations include the study's modest sample size, potential confounding factors like treatment effects, and the investigation of only three genetic variants.
