Comparative evaluation of antibacterial efficacy of nonsteroidal anti-inflammatory medications and proton-pump inhibitor against Enterococcus faecalis : An in vitro study

Journal of Conservative Dentistry : JCD · 6 authors, 1 centre

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TL;DR

The combination of TAP + PPI showed the greatest zone of bacterial inhibition, significantly outperforming all other tested medicaments.

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The diameter of bacterial inhibition zones was measured. The study concludes TAP+PPI is superior to all other tested medicaments.

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other

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preclinical research

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ORIGINAL PAPER

PMC10003294

Comparative evaluation of antibacterial efficacy of nonsteroidal anti-inflammatory medications and proton-pump inhibitor against Enterococcus faecalis : An in vitro study

Journal of Conservative Dentistry : JCD

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ABSTRACT

Abstract Aim: The present in vitro experimental study was undertaken to evaluate and compare the antimicrobial activity of triple antibiotic paste (TAP), diclofenac, and proton-pump inhibitor (PPI) against the microorganism Enterococcus faecalis. Materials and Methods: Three medicaments were selected for the study, TAP, diclofenac, and PPI. The experimental groups for the test were as follows: Part 1 – Group 1: TAP, Group 2: diclofenac, and Group 3: PPI; Part 2 – Group 1: TAP + PPI and Group 2: diclofenac + PPI. An agar well diffusion test was used to determine the efficacy of the experimental medicaments against E. faecalis (ATCC 29212). The diameter of inhibition zones was measured in millimeters using an inhibition zone measuring scale and the results were recorded. Statistical Analysis: The statistical analysis was done using an analysis of variance and an unpaired t -test. P value was set at < 0.05. Results: There was a significant difference in the diameter of growth inhibition zones, with the greatest diameter noted for TAP + PPI followed by diclofenac sodium (DS) + PPI, TAP, DS, and PPI. Conclusions: The antimicrobial effectiveness of TAP + PPI was found to be superior to all other medicaments (DS + PPI, TAP, DS, and PPI). Keywords: Diclofenac sodium, Enterococcus faecalis, proton-pump inhibitor, triple antibiotic paste

CITATION EXPORT

Akansha Tilokani, Pratik Agrawal, Prasanti Kumari Pradhan et al.. Comparative evaluation of antibacterial efficacy of nonsteroidal anti-inflammatory medications and proton-pump inhibitor against Enterococcus faecalis: An in vitro study. Journal of Conservative Dentistry : JCD. (2022). https://doi.org/10.4103/jcd.jcd_419_22

AUTHORS

6 · 1 CENTRES

Akansha Tilokani, Pratik Agrawal, Prasanti Kumari Pradhan, Gaurav Patri, Nilormi Karmakar, Yash Sinha

1Department of Conservative Dentistry and Endodontics, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India