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TL;DR
QIAreach demonstrated high sensitivity against QFT-Plus but lower specificity compared to tuberculin skin test at a 10 mm induration threshold.
Scientific Reports · 14 authors, 5 centres
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QIAreach demonstrated high sensitivity against QFT-Plus but lower specificity compared to tuberculin skin test at a 10 mm induration threshold.
QIAreach showed high sensitivity against QFT-Plus, concordant with prior studies reporting sensitivities of 99.1 to 100%. When compared to TST, QIAreach achieved significantly higher sensitivity with a statistically equivalent specificity at a 5 mm threshold, but lower specificity at a 10 mm threshold. Almost a quarter of recruited participants did not complete TST interpretation, highlighting TST's operational limitations. Limitations include the absence of bacteriological confirmation, a community setting with comparatively lower TB infection rates that may have introduced confounding, and no health economic analysis.