Journal of Current Glaucoma Practice · 6 authors, 2 centres
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This study used proteomic analysis of pooled aqueous humor samples from 15 pseudoexfoliation syndrome (PEX) patients and 15 matched cataract controls. The central result was the identification of 10 differentially expressed proteins, with apolipoprotein A4 and transthyretin being significantly overexpressed in the PEX group.
Researchers performed a comparative proteomic analysis of aqueous humor (AH) from 15 patients with pseudoexfoliation syndrome (PEX) and 15 matched controls with cataracts. Ingenuity Pathway Analysis suggested the liver X receptor/retinoid X receptor (LXR/RXR) pathway may be involved in PEX pathophysiology. The study's primary limitation is the use of pooled samples, which prevents analysis of individual variation. The findings suggest specific altered proteins and pathways in PEX AH, potentially contributing to understanding its molecular mechanisms.
