Scientific Reports · 6 authors, 6 centres
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This systematic review and meta-analysis compared antithrombin activity assays for detecting heparin binding site deficiency mutations (AT Budapest III and AT Padua I). Innovance and Labexpert were identified as the most sensitive assays for detecting both mutations.
This systematic review and meta-analysis compared Innovance antithrombin activity assays with other assays for detecting patients with heparin binding site antithrombin deficiency, focusing on AT Budapest III and AT Padua I mutations. Meta-analyses used standardised mean antithrombin activity differences with a random effects model and REML approach. The authors found that Innovance and Labexpert are the most sensitive assays for detection of both mutations. Sta-Stachrom also showed good performance for detection of AT Budapest III. The certainty of evidence was generally of moderate quality according to GRADE. Most meta-analyses included only two studies and sometimes fewer than 30 patients. Key limitations included unavailability of detailed population age and sex data, potential inter-laboratory variability, missing data imputed with mean values, and exclusion of pre-2009 studies. The authors recommend a large cross-sectional study to confirm these results.
