SEARCHCOHORTgastroenterology, emergency medicine

cohort·gastroenterology, emergency medicine, internal medicine, clinical trial, observational study·PMC10352050

Comparison of Interleukin-6, C-Reactive Protein, Procalcitonin, and the Computed Tomography Severity Index for Early Prediction of Severity of Acute Pancreatitis

Gut and Liver · 5 authors, 2 centres

AI SUMMARY

FIDELITY 100%

POPULATION103 patients hospitalized with acute pancreatitis

INTERVENTIONMeasurement of inflammatory markers (IL-6, CRP, procalcitonin) and scoring systems (CTSI, BISAP, Ranson, APACHE II) at admission

COMPARISONMild acute pancreatitis versus more severe forms, defined by the revised Atlanta classification

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This retrospective study of 103 hospitalized patients compared inflammatory markers and scoring systems for early prediction of mild acute pancreatitis. It found that interleukin-6 (IL-6) measured at admission, C-reactive protein measured 24 hours after admission (CRP2), and the CT severity index (CTSI) were useful predictors.

Full summary

836 CHARS

This was a retrospective cohort study of 103 hospitalized patients with acute pancreatitis. The study aimed to compare the ability of inflammatory markers (IL-6, CRP, procalcitonin) and various scoring systems (CTSI, BISAP, Ranson, APACHE II) to predict mild disease severity at admission. The central finding was that IL-6 measured at admission, CRP measured 24 hours after admission, and the CTSI were useful predictors of mild acute pancreatitis, with AUROCs of 0.755, 0.787, and 0.851, respectively. The study concluded these markers are helpful for early differentiation. Limitations include the retrospective, single-center design and the lack of routine measurement for all patients, which may introduce bias. The implications are that these markers may aid in early clinical decision-making for patients with acute pancreatitis.

PICO

PPOPULATION

103 patients hospitalized with acute pancreatitis

IINTERVENTION

Measurement of inflammatory markers (IL-6, CRP, procalcitonin) and scoring systems (CTSI, BISAP, Ranson, APACHE II) at admission

OOUTCOME

Ability to differentiate mild from severe acute pancreatitis

STUDY TYPE

cohort

SPECIALTY

gastroenterology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10352050

Comparison of Interleukin-6, C-Reactive Protein, Procalcitonin, and the Computed Tomography Severity Index for Early Prediction of Severity of Acute Pancreatitis

Gut and Liver

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ABSTRACT

Background/Aims Acute pancreatitis (AP) is a common gastrointestinal disease associated with hospitalization. With the increase in its incidence, AP has become a greater burden on healthcare resources. Early identification of patients with mild AP can facilitate the appropriate use of resources. We aimed to investigate the ability of inflammatory markers, including interleukin-6 (IL-6), procalcitonin, and C-reactive protein (CRP), as well as various scoring systems to differentiate mild AP from more severe diseases. Methods We retrospectively investigated patients hospitalized with AP, for whom severity assessment and clinical course confirmation were possible. Inflammatory markers were measured at admission, and CRP levels were measured 24 hours after admission (CRP2). Predictive values were calculated using the area under the receiver operating characteristic curve (AUROC) and logistic regression model analysis. Results Of 103 patients with AP, 42 (40.8%) were diagnosed with mild AP according to the revised Atlanta classification. Based on the AUROC, IL-6 (0.755, p<0.001), CRP2 (0.787, p<0.001), and computed tomography severity index (CTSI) (0.851, p<0.001) were useful predictors of mild AP. With standard cutoff values, the diagnostic sensitivity, specificity, and accuracy were 83.3%, 62.3%, and 70.9% for IL-6 (<50 pg/mL), and 78.6%, 63.9%, and 69.9% for CRP2 (<50 mg/L), respectively. The AUROC of IL-6 and CRP2 were significantly higher than those of other inflammatory markers and were not significantly different from that of CTSI. Conclusions IL-6, CRP2, and CTSI are helpful for early differentiation of AP severity. Among inflammatory markers, IL-6 has the advantage of early prediction of mild pancreatitis at the time of admission.

CITATION EXPORT

In Rae Cho, Min Young Do, So Young Han et al.. Comparison of Interleukin-6, C-Reactive Protein, Procalcitonin, and the Computed Tomography Severity Index for Early Prediction of Severity of Acute Pancreatitis. Gut and Liver. (2023). https://doi.org/10.5009/gnl220356

AUTHORS

5 · 2 CENTRES

In Rae Cho, Min Young Do, So Young Han, Sung Ill Jang, Jae Hee Cho

1Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, and
2Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea