Biological Trace Element Research · 7 authors, 5 centres
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In a cross-sectional study of 44 women with PCOS and 50 non-PCOS controls, no significant differences were found in 24-h urinary magnesium content (P=0.22), fractional excretion of magnesium (P=0.24), or serum magnesium (P=0.17) between the groups, suggesting magnesium status was similar and neither group was magnesium deficient.
This cross-sectional study compared magnesium status between 44 PCOS women and 50 non-PCOS infertile control women at an academic infertility clinic in Iran during 2021. PCOS diagnosis was based on Rotterdam criteria. Serum Mg levels were similar between groups (P=0.17), as was the Ca/Mg ratio (P=0.26). BMI was significantly higher in the PCOS group (P=0.002). Both groups had FEMg values well above the 0.5% threshold, suggesting neither group was magnesium deficient. The authors note that sample size was insufficient to assess BMI as a confounder, all participants were infertile (limiting external validity), and dietary intake was not formally assessed. The authors recommend using FEMg rather than serum Mg for evaluating magnesium status.
