Life · 1 author, 1 centre
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A multicentre cross-sectional study of 1033 patients across 12 Spanish primary eye care centres compared the OSDI and SANDE dry eye symptom questionnaires. The two instruments correlated moderately overall but showed significant score differences in symptomatic patients and poor correlation in moderate-to-severe dry eye, suggesting they are not interchangeable without score normalization.
Both questionnaires were administered by trained investigators at a single visit following a standardized protocol. The OSDI classified 291 patients (28.2%) as dry eye symptomatic using a cutoff of 12. Bland-Altman analysis revealed significant systematic bias between the instruments, with all differences showing significant linear correlation with the mean value (R² > 0.31; p < 0.001). Score normalization reduced but did not eliminate significant differences between the questionnaires.
