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TL;DR
Early medical management led to good outcomes in two patients, while a third with diffuse disease required liver transplantation.
JPGN reports · 8 authors, 4 centres
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Early medical management led to good outcomes in two patients, while a third with diffuse disease required liver transplantation.
Consumptive hypothyroidism is attributed to overexpression of deiodinase type 3 by vascular endothelium within hemangiomas, inactivating thyroid hormones. All three patients had normal neonatal thyroid screening but developed severe hypothyroidism subsequently. Two patients with multifocal disease responded to medical management including levothyroxine and hemangioma-directed therapy, with normalization of thyroid function as hemangioma size decreased. The third patient with diffuse disease and no cutaneous hemangiomas ultimately required liver transplantation.