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TL;DR
The review synthesizes laboratory-scale studies across chitosan, cellulose, pectin, and alginate systems, noting that clinical translation remains at an early stage.
Pharmaceutics · 1 author, 1 centre
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The review synthesizes laboratory-scale studies across chitosan, cellulose, pectin, and alginate systems, noting that clinical translation remains at an early stage.
The authors summarize laboratory studies employing mathematical release models—principally Korsmeyer-Peppas, Ritger-Peppas, Higuchi, and zero/first-order kinetics—to characterize release mechanisms from nanostructured matrices. Limitations include the restriction to in vitro and preclinical data, variability across studies in models and conditions, and the absence of clinical trial data. The authors conclude that while polysaccharide nanocarriers show promising sustained-release properties, substantial work on manufacturing, scale-up, and regulatory pathways is required before clinical application.