SEARCHNARRATIVE_REVIEWbiomedical research, preclinical research

narrative_review·biomedical research, preclinical research, research methods·PMC10046132

Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds

Biomimetics · 10 authors, 3 centres

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TL;DR

It concludes that their combination is promising but faces significant technical challenges for future clinical application.

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It outlines the essential properties of scaffolds and discusses how nanomaterials can enhance their mechanical and biological functions. The review describes the synergistic potential of combining these technologies for biological manufacturing but highlights persistent challenges. The authors suggest that overcoming these hurdles could improve tissue regeneration and lead to wider clinical application.

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narrative_review

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biomedical research

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ORIGINAL PAPER

PMC10046132

Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds

Biomimetics

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ABSTRACT

Abstract Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over scaffold geometry and microstructure. Nanobiomaterials as bioinks play a key role in manipulating the cellular microenvironment to alter its growth and development. This review first introduces the commonly used nanomaterials in tissue engineering scaffolds, including natural polymers, synthetic polymers, and polymer derivatives, and reveals the improvement of nanomaterials on scaffold performance. Second, the 3D bioprinting technologies of inkjet-based bioprinting, extrusion-based bioprinting, laser-assisted bioprinting, and stereolithography bioprinting are comprehensively itemized, and the advantages and underlying mechanisms are revealed. Then the convergence of 3D bioprinting and nanotechnology applications in tissue engineering scaffolds, such as bone, nerve, blood vessel, tendon, and internal organs, are discussed. Finally, the challenges and perspectives of convergence of 3D bioprinting and nanotechnology are proposed. This review will provide scientific guidance to develop 3D bioprinting tissue engineering scaffolds by nanotechnology. Keywords: 3D bioprinting, nanobiomaterials, nanotechnology, tissue engineering scaffolds

CITATION EXPORT

Shike Zhang, Xin Chen, Mengyao Shan et al.. Convergence of 3D Bioprinting and Nanotechnology in Tissue Engineering Scaffolds. Biomimetics. (2023). https://doi.org/10.3390/biomimetics8010094

AUTHORS

10 · 3 CENTRES

Shike Zhang, Xin Chen, Mengyao Shan, Zijuan Hao, Xiaoyang Zhang, Lingxian Meng, Zhen Zhai, Linlin Zhang, Xuying Liu, Xianghong Wang

1Henan Innovation Center for Functional Polymer Membrane Materials, Henan Key Laboratory of Advanced Nylon Materials and Application, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
2National Engineering Research Center of Wheat and Corn Further Processing, College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China
3Henan Innovation Center for Functional Polymer Membrane Materials, Xinxiang 453000, China