SEARCHCROSS-SECTIONALgeriatrics, endocrinology

cross-sectional·geriatrics, endocrinology, epidemiology, internal medicine, observational study·PMC10133547

Correlation of hemoglobin with osteoporosis in elderly Chinese population: A cross-sectional study

Frontiers in Public Health · 10 authors, 6 centres

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TL;DR

This cross-sectional study of 1,068 elderly Chinese individuals found that lower hemoglobin levels were associated with lower bone mineral density and a higher odds ratio for osteoporosis.

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A cross-sectional study enrolled 1,068 Chinese adults aged 55–85 years. Hemoglobin levels were measured, and bone mineral density (BMD) at the lumbar spine, femur neck, and total hip was assessed by dual-energy X-ray absorptiometry. Univariate and multivariate linear regression analyses showed hemoglobin levels were positively correlated with BMD at all measured sites after adjusting for gender, age, body mass index, diabetes mellitus, and morphological vertebral fracture. The study concludes that lower hemoglobin is related to lower bone mass and a higher odds ratio for osteoporosis. Limitations include the cross-sectional design, which precludes causal inference, and the lack of data on nutritional status and exercise levels.

STUDY TYPE

cross-sectional

SPECIALTY

geriatrics

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ORIGINAL PAPER

PMC10133547

Correlation of hemoglobin with osteoporosis in elderly Chinese population: A cross-sectional study

Frontiers in Public Health

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ABSTRACT

Introduction In the elder population, both low hemoglobin (Hb)/anemia and osteoporosis (OP) are highly prevalent. However, the relationship between Hb and OP is still poorly understood. This study was to evaluate the correlation between Hb and OP in Chinese elderly population. Methods One thousand and sisty-eight individuals aged 55–85 years were enrolled into this cross-sectional study during June 2019–November 2019. Data on the demographics and clinical characteristics were recorded. Detections of complete blood count, liver/kidney function, glucose metabolism and lipid profile, and thoracolumbar X-ray were performed, and bone mineral density (BMD) at lumbar spine 1–4, femur neck, and total hip was measured by dual-energy X-ray absorptiometry (DXA). Univariate and multivariate linear regression analyses were employed to evaluate the correlation between Hb with BMD T-score. Logistic regression analysis was performed to access the correlation between different Hb levels and the odds ratio (OR) for OP. Results Compared with non-OP group, OP patients had lower level of Hb. Univariate linear regression analysis indicated Hb level was positively related to the BMD of lumbar spine 1–4, femur neck and total hip, and this relationship remained after adjusting confounding variables [gender, age, body mass index (BMI), diabetes mellitus (DM) and morphological vertebral fracture]. Logistic regression analysis showed the ORs for OP decreased with the increase of Hb. Compared with the subjects with the lowest quartile of Hb, the OR for OP in the highest quartile group was 0.60 (0.41–0.89) after adjusting for gender, age and BMI, and the OR for OP was 0.62 (0.41–0.92) after further adjustment for gender, age, BMI, DM, and lipid indexes. Discussion In conclusion, Lower Hb level is related to lower BMD in the elderly population. However, whether Hb level could be used to predict the risk of OP needs to be further determined in more longitudinal clinical studies.

CITATION EXPORT

Yichen Liu, Yue Zeng, Jun Lu et al.. Correlation of hemoglobin with osteoporosis in elderly Chinese population: A cross-sectional study. Frontiers in Public Health. (2023). https://doi.org/10.3389/fpubh.2023.1073968

AUTHORS

10 · 6 CENTRES

Yichen Liu, Yue Zeng, Jun Lu, Xiaoya Zhang, Zikai Zhang, Huijuan Li, Peipei Liu, Bin Ma, Yiqun Gu, Lige Song

1Department of Endocrinology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
2Institute of Osteoporosis and Metabolic Bone Diseases, School of Medicine, Tongji University, Shanghai, China
3Department of Endocrinology and Metabolism, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
4Division of Science and Research, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
5Division of Spine, Department of Orthopedics, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
6Ganquan Community Health Service Center, Shanghai, China