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TL;DR
Dialysate cooling significantly reduced intradialytic hypotension episodes but did not lead to significant improvements in nutritional or inflammatory markers compared to standard care.
BMC Nephrology · 4 authors, 3 centres
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Dialysate cooling significantly reduced intradialytic hypotension episodes but did not lead to significant improvements in nutritional or inflammatory markers compared to standard care.
Primary outcomes included changes in inflammatory markers (HS-CRP, IL-6), nutritional parameters (serum albumin, malnutrition-inflammation score), and the incidence of intradialytic hypotension. The central result showed that dialysate cooling significantly reduced the prevalence and total episodes of intradialytic hypotension. While the intervention group saw significant reductions in serum ferritin, transferrin saturation, HS-CRP, and IL-6, and a rise in serum albumin, similar improvements in albumin and a drop in IL-6 were also observed in the control group, preventing a definitive causal link to cooling. Limitations include the small sample size, short follow-up duration, and lack of control for confounding factors like infections. The findings suggest cooling is safe and effective for reducing hypotension but does not conclusively improve nutritional or inflammatory status.