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TL;DR
However, the evidence is very limited, with no randomized clinical trials and high or unclear risk of bias in most included studies.
Clinical Oral Investigations · 7 authors, 4 centres
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However, the evidence is very limited, with no randomized clinical trials and high or unclear risk of bias in most included studies.
Data synthesis was descriptive due to limited study numbers and heterogeneity. Human studies showed short-term reductions in gingival crevicular fluid volume and periodontal biomarkers in the absence of periodontal treatment, though effects in one study were observed only in women. All included studies had high or unclear risk of bias, the two human studies had only four months of follow-up, and three of four animal studies came from a single research group. The authors conclude that caloric restriction shows potential to reduce local and systemic inflammation related to periodontitis but emphasize that methodologically robust randomized controlled trials with longer follow-up are needed.