International Journal of Molecular Sciences · 8 authors, 5 centres
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This cross-sectional study measured TLR2 expression on various peripheral blood immune cells in gastric cancer patients versus controls. The central result was that TLR2 expression was significantly higher in cancer patients and increased with more advanced disease stage.
The study investigated whether TLR2 expression on peripheral blood immune cells could serve as a biomarker for gastric cancer. Researchers analyzed TLR2 percentages on CD4+ T cells, CD8+ T cells, B lymphocytes, dendritic cells, and monocyte subtypes in gastric cancer patients and compared them to a control group. The analysis used statistical methods including the Mann-Whitney U test, Kruskal-Wallis test, and ROC curve analysis. The key finding was a significantly higher percentage of all tested immune cell populations expressing TLR2 in cancer patients compared to controls. Furthermore, TLR2 expression showed a significant link with disease stage, increasing with more advanced stages on the TNM scale. The authors suggest this indicates a role for TLR2 in gastric cancer immunopathogenesis and support its potential diagnostic utility for specific cell types.
