SEARCHNARRATIVE_REVIEWnephrology, geriatrics

narrative_review·nephrology, geriatrics, infectious disease, internal medicine·PMC10046485

COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review

Biomedicines · 4 authors, 3 centres

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TL;DR

The review notes that mortality rates in dialysis populations are significantly higher compared to historical controls.

Full summary

327 CHARS

The review notes that mortality rates in dialysis populations are significantly higher compared to historical controls. The authors conclude that while directive guidance is emerging, there remains limited specific data on treatment efficacy and adverse events for this cohort, highlighting a need for further focused research.

STUDY TYPE

narrative_review

SPECIALTY

nephrology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10046485

COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review

Biomedicines

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ABSTRACT

Abstract There is an increased incidence of elderly adults diagnosed with kidney failure as our global aging population continues to expand. Hence, the number of elderly adults indicated for kidney replacement therapy is also increasing simultaneously. Haemodialysis initiation is more commonly observed in comparison to kidney transplantation and peritoneal dialysis for the elderly. The onset of the coronavirus 2019 (COVID-19) pandemic brought new paradigms and insights for the care of this patient population. Elderly patients receiving haemodialysis have been identified as high-risk groups for poor COVID-19 outcomes. Age, immunosenescence, impaired response to COVID-19 vaccination, increased exposure to sources of COVID-19 infection and thrombotic risks during dialysis are key factors which demonstrated significant associations with COVID-19 incidence, severity and mortality for this patient group. Recent findings suggest that preventative measures such as regular screening and, if needed, isolation in COVID-19-positive cases, alongside the fulfillment of COVID-19 vaccination programs is an integral strategy to reduce the number of COVID-19 cases and consequential complications from COVID-19, particularly for high-risk groups such as elderly haemodialysis patients. The COVID-19 pandemic brought about the rapid development and repurposing of a number of medications to treat patients in the viral and inflammatory stages of their disease. However, elderly haemodialysis patients were grossly unrepresented in many of these trials. We review the evidence for contemporary treatments for COVID-19 in this population to provide clinicians with an up-to-date guide. We hope our article increases awareness on the associations and impact of COVID-19 for the elderly haemodialysis population, and encourage research efforts to address knowledge gaps in this topical area. Keywords: Coronavirus 2019, elderly patients, haemodialysis, risk factors, pathophysiology, prevention, management

CITATION EXPORT

Thomas McDonnell, Henry H L Wu, Philip A Kalra et al.. COVID-19 in Elderly Patients Receiving Haemodialysis: A Current Review. Biomedicines. (2023). https://doi.org/10.3390/biomedicines11030926

AUTHORS

4 · 3 CENTRES

Thomas McDonnell, Henry H L Wu, Philip A Kalra, Rajkumar Chinnadurai

1Department of Renal Medicine, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK
2Renal Research Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, NSW 2065, Australia
3Faculty of Biology, Medicine & Health, The University of Manchester, Manchester M1 7HR, UK