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case-control·pediatric ophthalmology, pediatrics, infectious disease, epidemiology, public health·PMC10492677

Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome

Clinical Oral Investigations · 6 authors, 7 centres

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TL;DR

CZS children presented microcephaly, prognathic maxilla, retrognathic mandible, altered facial thirds, and tongue protrusion.

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CZS children presented microcephaly, prognathic maxilla, retrognathic mandible, altered facial thirds, and tongue protrusion. Bruxism was significantly more prevalent in CZS (p=0.006), and distal step decidual molar relationship was significantly associated with CZS (p=0.031). Twelve CZS children were fed liquids and soft diet, and caries frequency was higher in CZS but not statistically significant. Dental eruption delays were noted in four CZS children. No differences were found in dental formula or dental morphology between groups.

STUDY TYPE

case-control

SPECIALTY

pediatric ophthalmology

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ORIGINAL PAPER

PMC10492677

Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome

Clinical Oral Investigations

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ABSTRACT

Abstract Objective Zika virus infection has been associated to congenital zika syndrome (CZS) in newborns and is characterized by microcephaly, central/axial motor and sensory dysfunction, dysphagia among other previously described severe health complications. CZS is usually diagnosed postpartum by evident/apparent neural development problems. Although there are some reports of craniofacial/dentition development in CZS, several clinical oral aspects are still unknown. This study describes some structural and functional characteristics of facial and cranial growth and deciduous dentition in CZS-affected children. Material and methods Some cranial, facial and dental characteristics were determined in 14 children with CZS aged 3–5 years and compared them against 12 apparently healthy children paired by age and gender. Results Fourteen CZS cases presented microcephaly, maxillary prognathism, altered facial thirds, asymmetric pupillary line, bruxism ( p = 0.006), deep and anterior open bite and distal step decidual molar relationship ( p = 0.031). CZS children cannot feed by themselves and most cannot walk and have not develop coordinated and intelligible language according to their chronological age. In contrast, controls presented normal skull features, have autonomous locomotion skills, speak intelligible language, feed by themselves, presented a harmonic intermaxillary relationship and have symmetrical facial thirds. Conclusion Microcephaly, dysphagia, bruxism, mandibular retrognathia, altered facial proportions and malocclusion are the main craniofacial and oral features at CZS. Clinical relevance The complications of CZS including those related with the face and the oral cavity are still being identified. This study revealed some cranial, facial and oral features in children affected by CSZ. Interdisciplinary rehabilitation protocols must address these syndromic features that could improve children and parents living conditions. Keywords: Children-anthropometry, Craniofacial features, Maxillofacial abnormalities, Dentition, Congenital Zika virus

CITATION EXPORT

Catalina Díaz, Natalia Aragón, Eduardo Lopez-Medina et al.. Craniofacial and dental features in children aged 3–5 years with congenital Zika syndrome. Clinical Oral Investigations. (2023). https://doi.org/10.1007/s00784-023-05137-5

AUTHORS

6 · 7 CENTRES

Catalina Díaz, Natalia Aragón, Eduardo Lopez-Medina, Maria Cristina Arango, Diana Dávalos, Adolfo Contreras-Rengifo

1Advanced Program Pediatric Dentistry and Maxillary Orthopedics, Universidad del Valle, Cali, Colombia
2School of Dentistry, Universidad del Valle, Cali, Colombia
3PhD Biomedical Sciences, Universidad del Valle, Cali, Colombia
4Periodontal Medicine Group, Universidad del Valle, Calle 3# 36 B 00 Building 132, Cali, Colombia
5School of Medicine, Universidad del Valle, Cali, Colombia
6Center for Studies in Pediatric Infectology, CEIP, Cali, Colombia
7Quironsalud Group Clínica Imbanaco, Cali, Colombia