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TL;DR
This preclinical study used cell line models to show that iron is essential for the early stage of adipocyte differentiation, enabling epigenetic demethylation of genes like Pparg via the enzymes JMJD1A and TET2.
Nucleic Acids Research · 23 authors, 26 centres
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This preclinical study used cell line models to show that iron is essential for the early stage of adipocyte differentiation, enabling epigenetic demethylation of genes like Pparg via the enzymes JMJD1A and TET2.
The authors demonstrated that iron supply via lysosome-mediated ferritinophagy is crucial during the early differentiation stage. Iron deficiency suppressed the activity of the histone demethylase JMJD1A and the DNA demethylase TET2, leading to reduced demethylation of repressive marks and suppression of key adipogenic genes like Pparg. An integrated analysis suggested that histone demethylation precedes DNA demethylation. The study identifies iron as a key regulator of epigenetic enzyme activity during adipogenesis.