SEARCHNARRATIVE_REVIEWresearch methods, surgery

narrative_review·research methods, surgery, oncology, biomedical research, preclinical research·PMC10827820

Current and Developing Lymphatic Imaging Approaches for Elucidation of Functional Mechanisms and Disease Progression

Molecular Imaging and Biology · 2 authors, 2 centres

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TL;DR

This narrative review discusses various lymphatic imaging techniques, such as lymphoscintigraphy, near-infrared fluorescence (NIRF), and photoacoustic imaging, and evaluates their applications in understanding lymphatic anatomy, diagnosing lymphedema, and mapping sentinel lymph nodes in cancer.

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This narrative review article surveys the role of lymphatic imaging techniques in advancing the understanding of the lymphatic system's anatomy, physiology, and disease involvement. The authors discuss established methods like lymphoscintigraphy and emerging modalities such as near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG) and photoacoustic imaging. The review also highlights applications in cancer care, particularly sentinel lymph node mapping for surgical planning. Limitations include the depth constraints of NIRF and the need for further validation of newer techniques against established gold standards.

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narrative_review

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research methods

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ORIGINAL PAPER

PMC10827820

Current and Developing Lymphatic Imaging Approaches for Elucidation of Functional Mechanisms and Disease Progression

Molecular Imaging and Biology

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ABSTRACT

Study of the lymphatic system, compared to that of the other body systems, has been historically neglected. While scientists and clinicians have, in recent decades, gained a better appreciation of the functionality of the lymphatics as well as their role in associated diseases (and consequently investigated these topics further in their experimental work), there is still much left to be understood of the lymphatic system. In this review article, we discuss the role lymphatic imaging techniques have played in this recent series of advancements and how new imaging techniques can help bolster this wave of discovery. We specifically highlight the use of lymphatic imaging techniques in understanding the fundamental anatomy and physiology of the lymphatic system; investigating the development of lymphatic vasculature (using techniques such as intravital microscopy); diagnosing, staging, and treating lymphedema and cancer; and its role in other disease states.

CITATION EXPORT

Arjun Aron, Cristina Zavaleta. Current and Developing Lymphatic Imaging Approaches for Elucidation of Functional Mechanisms and Disease Progression. Molecular Imaging and Biology. (2023). https://doi.org/10.1007/s11307-023-01827-4

AUTHORS

2 · 2 CENTRES

Arjun Aron, Cristina Zavaleta

1https://ror.org/03taz7m60grid.42505.360000 0001 2156 6853Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, CA 90089 USA
2https://ror.org/03taz7m60grid.42505.360000 0001 2156 6853Michelson Center for Convergent Bioscience, University of Southern California, 1002 Childs Way, Los Angeles, CA 90089 USA