SEARCHSYSTEMATIC_REVIEWgastroenterology, epidemiology

systematic_review·gastroenterology, epidemiology, public health, systematic review, cardiology·PMC10522780

Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes

Hepatology International · 7 authors, 3 centres

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The authors searched multiple databases up to May 2023 and included studies comparing the two definitions.

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The authors searched multiple databases up to May 2023 and included studies comparing the two definitions. The review also suggests greater granularity in risk-stratification among MAFLD subtypes. A key limitation noted is that the impact of the nomenclature change on non-fatal clinical outcomes like cardiovascular disease, liver decompensation, and malignancy needs further investigation. The findings highlight shifts in epidemiological estimates and mortality risk based on diagnostic criteria.

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systematic_review

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gastroenterology

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ORIGINAL PAPER

PMC10522780

Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes

Hepatology International

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ABSTRACT

Abstract Introduction For the first time in nearly half a century, fatty liver disease has undergone a change in name and definition, from the exclusive term, non-alcoholic fatty liver disease (NAFLD), to the inclusion-based, metabolic-associated fatty liver disease (MAFLD). This has led investigators across the globe to evaluate the impact the nomenclature change has had on the epidemiology and natural history of the disease. Methods This systematic review provides a comprehensive overview on how the shift in name and diagnostic criteria has influenced point prevalence in different geographic regions, as well as morbidity and mortality risk, whilst highlighting gaps in the literature that need to be addressed. Conclusions MAFLD prevalence is higher than NAFLD prevalence, carries a higher risk of overall mortality, with greater granularity in risk-stratification amongst MAFLD subtypes. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s12072-023-10568-z. Keywords: NAFLD, MAFLD, Epidemiology, Prevalence, Mortality, Morbidity, Cardiovascular disease, Liver-related outcome, Cancer, Hepatocellular carcinoma

CITATION EXPORT

Karl Vaz, Daniel Clayton-Chubb, Ammar Majeed et al.. Current understanding and future perspectives on the impact of changing NAFLD to MAFLD on global epidemiology and clinical outcomes. Hepatology International. (2023). https://doi.org/10.1007/s12072-023-10568-z

AUTHORS

7 · 3 CENTRES

Karl Vaz, Daniel Clayton-Chubb, Ammar Majeed, John Lubel, David Simmons, William Kemp, Stuart K Roberts

1Department of Gastroenterology and Hepatology, Ground Floor Alfred Centre, Alfred Health, 55 Commercial Road, Melbourne, VIC 3004 Australia
2Central Clinical School, Monash University, Melbourne, Australia
3Macarthur Clinical School, School of Medicine, Western Sydney University, Campbelltown, Australia