Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6–7 Years: A Follow-Up of a Randomized Controlled Trial

The Journal of Nutrition · 7 authors, 5 centres

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FIDELITY 100%

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TL;DR

This study is a follow-up to a randomized controlled trial where children aged 6–30 months received daily supplements of vitamin B12, folic acid, both, or a placebo for 6 months.

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This study is a follow-up to a randomized controlled trial where children aged 6–30 months received daily supplements of vitamin B12, folic acid, both, or a placebo for 6 months. Subgroup analyses suggested vitamin B12 supplementation might lower leptin-related ratios in stunted or underweight children. The findings suggest a persistent effect of early childhood micronutrient supplementation on a heart disease risk marker.

STUDY TYPE

RCT

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10196576

Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6–7 Years: A Follow-Up of a Randomized Controlled Trial

The Journal of Nutrition

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ABSTRACT

Background Deficiencies of vitamin B12 and folate are associated with elevated concentrations of metabolic markers related to CVDs. Objectives We investigated the effect of supplementation of vitamin B12 with or without folic acid for 6 mo in early childhood on cardiometabolic risk markers after 6–7 y. Methods This is a follow-up study of a 2 × 2 factorial, double-blind, randomized controlled trial of vitamin B12 and/or folic acid supplementation in 6–30-mo-old children. The supplement contained 1.8 μg of vitamin B12, 150 μg of folic acid, or both, constituting >1 AI or recommended daily allowances for a period of 6 mo. Enrolled children were contacted again after 6 y (September 2016–November 2017), and plasma concentrations of tHcy, leptin, high molecular weight adiponectin, and total adiponectin were measured ( N = 791). Results At baseline, 32% of children had a deficiency of either vitamin B12 (<200 pmol/L) or folate (<7.5 nmol/L). Combined supplementation of vitamin B12 and folic acid resulted in 1.19 μmol/L (95% CI: 0.09; 2.30 μmol/L) lower tHcy concentration 6 y later compared to placebo. We also found that vitamin B12 supplementation was associated with a lower leptin–adiponectin ratio in subgroups based on their nutritional status. Conclusions Supplementation with vitamin B12 and folic acid in early childhood was associated with a decrease in plasma tHcy concentrations after 6 y. The results of our study provide some evidence of persistent beneficial metabolic effects of vitamin B12 and folic acid supplementation in impoverished populations. The original trial was registered at www.clinicaltrials.gov as NCT00717730 , and the follow-up study at www.ctri.nic.in as CTRI/2016/11/007494.

CITATION EXPORT

Rukman Manapurath, Tor A. Strand, Ranadip Chowdhury et al.. Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6–7 Years: A Follow-Up of a Randomized Controlled Trial. The Journal of Nutrition. (2023). https://doi.org/10.1016/j.tjnut.2023.03.003

AUTHORS

7 · 5 CENTRES

Rukman Manapurath, Tor A. Strand, Ranadip Chowdhury, Ingrid Kvestad, Chittaranjan S. Yajnik, Nita Bhandari, Sunita Taneja

1Centre for Health Research and Development, Society for Applied Studies, Delhi, India
2Centre for International Health, University of Bergen, Norway
3Department of Research, Innlandet Hospital Trust, Lillehammer, Norway
4Regional Centre for Child and Youth Mental Health and Child Welfare, West, Norwegian Research Centre, Bergen, Norway
5Diabetes Unit, King Edward Memorial Hospital and Research Centre, Pune, India