Decreasing incidence of hepatocellular carcinoma among most racial groups: SEER ‐22, 2000–2019

Cancer Medicine · 5 authors, 2 centres

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FIDELITY 100%

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

The analysis identified joinpoints for significant changes in annual percent change (APC).

Full summary

836 CHARS

The analysis identified joinpoints for significant changes in annual percent change (APC). The central result is that overall HCC incidence peaked in 2015 at a rate of 10.03 per 100,000 person-years, then declined significantly to 9.20 in 2019 (APC: −2.25%). This decline was observed in most racial/ethnic groups, though with different onset years: Asian/Pacific Islanders (2007), White and Hispanic populations (2014), and Black individuals (2016). Incidence continued to rise in the American Indian/Alaska Native population, though not significantly, and in individuals aged 75+. Wide disparities persisted; in 2019, rates in American Indian/Alaska Native and Hispanic populations were more than twice that of White individuals. The study is limited to registry catchment areas and does not explain the causes of the observed trends.

STUDY TYPE

other

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10587941

Decreasing incidence of hepatocellular carcinoma among most racial groups: SEER ‐22, 2000–2019

Cancer Medicine

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ABSTRACT

Abstract Background Hepatocellular carcinoma (HCC) incidence was rising in the United States. Previously, using data collected by the Surveillance, Epidemiology, and End Results (SEER) Program through 2017, we found that overall incidence had begun to decline, although not in Black and American Indian/Alaska Native (AI/AN) populations. Utilizing expanded SEER data encompassing ~50% of the population, we examined secular trends and demographic differences in HCC incidence through 2019. Methods We included cases of HCC diagnosed in adults aged ≥20 years residing in SEER‐22 registry areas. We examined case counts, incidence rates (per 100,000 person‐years), annual percent changes (APCs), and calendar years when APCs changed significantly. Results HCC incidence increased from 5.56 in 2000 to 8.89 in 2009 (APC, 5.17%), then rose more slowly during 2009–2015 (APC, 2.28%). After peaking at 10.03 in 2015, incidence fell to 9.20 in 2019 (APC, −2.26%). In Asian/Pacific Islanders (A/PI), the decline began in 2007 and accelerated in 2015 (APCs: 2007–2015, −1.84%; 2015–2019, −5.80%). In 2014, incidence began to fall in the White (APC: 2014–2019, −1.11%) and Hispanic populations (APC: 2014–2019, −1.72%). In 2016, rates began to fall in Black individuals (APC: 2016–2019, −6.05%). In the AI/AN population, incidence was highest in 2017, although the subsequent decline was not statistically significant. In 2019, population‐specific rates were: White, 6.94; Black, 10.74; A/PI, 12.11; AI/AN, 14.56; Hispanic, 15.48. Conclusion HCC incidence is now decreasing in most US racial/ethnic populations, including among Black individuals. The onset of decline differed among racial/ethnic groups and wide disparities in HCC rates remain.

CITATION EXPORT

Thomas R. O'Brien, Susan S. Devesa, Jill Koshiol et al.. Decreasing incidence of hepatocellular carcinoma among most racial groups: SEER‐22, 2000–2019. Cancer Medicine. (2023). https://doi.org/10.1002/cam4.6537

AUTHORS

5 · 2 CENTRES

Thomas R. O'Brien, Susan S. Devesa, Jill Koshiol, Jorge A. Marrero, Meredith S. Shiels

1 Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland USA
2 Division of Gastroenterology and Hepatology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA