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TL;DR
The pipeline, comprising Time-Interval Principal Component Analysis and sliding dynamic hypergraphs, was applied to serial data on 100 preselected genes, including components of the Wnt/β-catenin pathway.
Hepatology Communications · 6 authors, 5 centres
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The pipeline, comprising Time-Interval Principal Component Analysis and sliding dynamic hypergraphs, was applied to serial data on 100 preselected genes, including components of the Wnt/β-catenin pathway.
The pipeline, comprising Time-Interval Principal Component Analysis and sliding dynamic hypergraphs, was applied to serial data on 100 preselected genes, including components of the Wnt/β-catenin pathway. Key findings include the identification of functional gene modules, inference that macrophage-mediated inflammation is critical in early regeneration, and confirmation that *Ccnd1* is regulated by the Wnt/β-catenin pathway. The study positions ADViSOR as a hypothesis-generating tool for spatiotemporal contexts, validated partially by protein localization.