SEARCHCASE-CONTROLophthalmology, oncology

case-control·ophthalmology, oncology, infectious disease, epidemiology·PMC10686408

Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa

Eye · 3 authors, 3 centres

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TL;DR

This prospective case-control study described the features of ocular surface squamous neoplasia (OSSN) at a South African eye hospital. It found HIV infection was strongly associated with OSSN, and the disease presented at a younger age with no gender predilection in this population.

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A fibrovascular morphology was strongly associated with benign lesions. The majority of OSSN cases (82%) were conjunctival intra-epithelial neoplasia (CIN). The findings describe a younger population of OSSN patients with HIV as a primary risk factor, differing from patterns in some other African studies.

STUDY TYPE

case-control

SPECIALTY

ophthalmology

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AI pipeline

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ORIGINAL PAPER

PMC10686408

Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa

Eye

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ABSTRACT

Abstract Aims The aim of this study is to describe the demographic, presenting features and associated risk factors of ocular surface squamous neoplasia (OSSN) at a tertiary eye hospital in Johannesburg, South Africa. Methods An interventional prospective study of patients presenting with conjunctival masses was conducted. An electronic questionnaire was completed to document demographic data, presenting history, and associated risk factors. A slit lamp examination and photos were used to document and describe the clinical features at presentation. Cases (OSSN) and controls (benign lesions) were determined by histology. Results There were 130 cases and 45 controls. Median age was 44 years (IQR: 35–51) with an equal gender distribution in cases. The prevalence of HIV in cases was 74% and was strongly associated with OSSN ( p < 0.001). Vascularisation, leukoplakia and pigmentation were clinical features that distinguished cases from controls. A fibrovascular morphology was strongly associated with a benign histology ( p < 0.001), whereas leukoplakic and gelatinous morphologies were associated with OSSN. Conjunctival intra-epithelial neoplasia made up 82% of cases. Conclusion Our study describes a sample of OSSN that is young and has no gender predisposition. The majority of cases presented with CIN lesions, rather than SCC reported in other African countries. HIV was the most significant risk factor in this study population. Subject terms: Eye manifestations, Risk factors, Conjunctival diseases, Eye cancer

CITATION EXPORT

Roland Hӧllhumer, Pamela Michelow, Susan Williams. Demographics, clinical presentation and risk factors of ocular surface squamous neoplasia at a tertiary hospital, South Africa. Eye. (2023). https://doi.org/10.1038/s41433-023-02565-1

AUTHORS

3 · 3 CENTRES

Roland Hӧllhumer, Pamela Michelow, Susan Williams

1Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa
2The Cornea Foundation, Johannesburg, South Africa
3Cytology Unit, National Health Laboratory Service and Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa