SEARCHCOHORTendocrinology, gastroenterology

cohort·endocrinology, gastroenterology, oncology, epidemiology, observational study·PMC10586863

Diabetes and the risk of cirrhosis and HCC: An analysis of the UK Biobank

Hepatology Communications · 3 authors, 5 centres

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This large prospective cohort study analyzed 449,497 UK Biobank participants to assess associations between diabetes status and incident liver cirrhosis and HCC.

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This large prospective cohort study analyzed 449,497 UK Biobank participants to assess associations between diabetes status and incident liver cirrhosis and HCC. Using Cox regression models, the researchers found that compared to normoglycemia, prediabetes was associated with aHRs of 1.41 for cirrhosis and 1.80 for HCC. Having <5 years or ≥5 years of diabetes showed aHRs for cirrhosis of 2.85 and 3.43, respectively, and even higher risks for HCC. The findings suggest that both clinical diabetes and preclinical stages are associated with adverse hepatic outcomes.

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cohort

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endocrinology

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ORIGINAL PAPER

PMC10586863

Diabetes and the risk of cirrhosis and HCC: An analysis of the UK Biobank

Hepatology Communications

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ABSTRACT

Abstract Background: Diabetes increases the risk of cirrhosis and HCC. We aimed to assess such associations given different diabetes statuses. Methods: We included 449,497 participants in the UK Biobank cohort (mean age 56.7±8.0 y; 45.5% male) and assessed the association between preclinical diabetes (prediabetes, having a high risk of diabetes), clinical diabetes (presence, duration, or glycemic control of type 2 diabetes), and incident liver cirrhosis and HCC by the Cox regression. Liver diseases were ascertained through inpatient records and national death registration. Gene-environment interaction was examined using the polygenic risk scores of cirrhosis and HCC. Results: Compared with normoglycemia, having <5 years,≥5 years of diabetes showed adjusted HRs (aHRs) of cirrhosis as 2.85 (2.45–3.32) and 3.43 (2.92–4.02), respectively, which was similarly observed in HCC. In diabetes, a level of hemoglobin A1c ≥ 7.5% showed aHRs of 1.37 (1.07–1.76) and 1.89 (1.10–3.25) for cirrhosis and HCC, respectively, compared with hemoglobin A1c < 6.5%. In non-diabetes, prediabetes presented aHRs of 1.41 (1.14–1.73) and 1.80 (1.06–3.04) of cirrhosis and HCC, respectively. Participants with a high risk of diabetes at baseline showed an aHR of 3.31 (2.65–4.13) for cirrhosis and 2.09 (1.15–3.80) for HCC. In those with a high genetic risk of HCC, having an increased risk of diabetes posed a significantly higher risk of HCC (aHR: 1.93, 1.45–2.58, P interaction =0.005), compared with those without a high genetic risk of HCC. Conclusions: Not only diabetes but preclinical diabetes, longer diabetes duration, and higher baseline hemoglobin A1c were associated with an increased risk of incident cirrhosis and HCC in the general population.

CITATION EXPORT

Fangzhou Ye, Liangkai Chen, Xin Zheng. Diabetes and the risk of cirrhosis and HCC: An analysis of the UK Biobank. Hepatology Communications. (2023). https://doi.org/10.1097/HC9.0000000000000280

AUTHORS

3 · 5 CENTRES

Fangzhou Ye, Liangkai Chen, Xin Zheng

1Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China
3Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
4Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
5Hubei Jiangxia Laboratory, Wuhan, China