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TL;DR
It highlights that chronic HDV infection leads to more severe liver disease than HBV monoinfection, including accelerated fibrosis, higher rates of cirrhosis and hepatocellular carcinoma (HCC), and earlier decompensation.
Digestive Diseases and Sciences · 6 authors, 8 centres
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It highlights that chronic HDV infection leads to more severe liver disease than HBV monoinfection, including accelerated fibrosis, higher rates of cirrhosis and hepatocellular carcinoma (HCC), and earlier decompensation.
It highlights that chronic HDV infection leads to more severe liver disease than HBV monoinfection, including accelerated fibrosis, higher rates of cirrhosis and hepatocellular carcinoma (HCC), and earlier decompensation. The review notes significant underdiagnosis due to low clinician awareness and complex testing pathways. The authors advocate for reflexive screening of HBV patients for HDV and state that immunization against HBV is the best prevention. They conclude that improved detection and emerging therapies are needed to address the substantial burden of liver disease progression.