SEARCHNARRATIVE_REVIEWobstetrics and gynecology, nutrition

narrative_review·obstetrics and gynecology, nutrition, dietetics, clinical nutrition, epidemiology·PMC10507348

Diet associations in endometriosis: a critical narrative assessment with special reference to gluten

Frontiers in Nutrition · 7 authors, 8 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review critically assessed observational and interventional studies examining associations between dietary components and endometriosis.

Full summary

557 CHARS

This narrative review critically assessed observational and interventional studies examining associations between dietary components and endometriosis. Observational data showed conflicting results regarding associations between specific foods and endometriosis prevalence, pain perception, or quality of life. The authors noted that symptom overlap between endometriosis and conditions such as irritable bowel syndrome and celiac disease complicates interpretation. Placebo and nocebo effects may contribute to patient-reported benefits of dietary changes.

STUDY TYPE

narrative_review

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10507348

Diet associations in endometriosis: a critical narrative assessment with special reference to gluten

Frontiers in Nutrition

READ THE FULL PAPER

ABSTRACT

Abstract Endometriosis is characterized by the presence of endometrium-like tissue outside the uterus. The etiology remains largely unknown. Despite adequate treatment, patients can still experience symptoms or side effects resulting in therapy incompliance and in self-management strategies such as dietary measures is increasing. A gluten free diet is thought to be contributory in reducing endometriosis-related pain, thereby optimizing quality of life. However, data is conflicting and currently provides no evidence for causality. This narrative review aims to put the effect of dietary self-management strategies on endometriosis in a balanced perspective, especially the effect of gluten and a gluten free diet. Several studies have found a strong overlap in symptoms, metabolic and immune responses associated with endometriosis and those associated with celiac disease, ulcerative colitis, Crohn’s disease, irritable bowel syndrome and non-celiac wheat sensitivity. However, it remains unclear whether these diseases and/or disorders are causal to an increased risk of endometriosis. Some studies have found a positive effect on the risk of endometriosis, endometriosis-related symptoms and quality of life (QoL) when women either avoided certain nutrients or foods, or applied a specific nutrient supplementation. This includes the avoidance of red meat, an increasing intake of foods rich in anti-oxidants, omega-3, micronutrients and dietary fibers (e.g., fruit, vegetables) and the appliance of a gluten free diet. However, data from the available studies were generally graded of low quality and it was noted that placebo and/or nocebo effects influenced the reported positive effects. In addition, such effects were no longer seen when adjusting for confounders such as overweight, when a translation was made from in vitro to in vivo , or when the nutrients were not supplemented as isolated sources but as part of a mixed daily diet. Finally, some studies showed that long-term adherence to a gluten free diet is often associated with an impaired diet quality and nutrient intake, leading to negative health outcomes and reduced QoL. Concluding, scientific evidence on the efficacy of dietary interventions on well-defined clinical endpoints of endometriosis is lacking and recommending a gluten free diet to women solely diagnosed with endometriosis should therefore not be advised. Keywords: endometriosis, diet associations, diet recommendations, omega-3, red meat, gluten-free

CITATION EXPORT

Fred Brouns, Annelotte Van Haaps, Daniel Keszthelyi et al.. Diet associations in endometriosis: a critical narrative assessment with special reference to gluten. Frontiers in Nutrition. (2023). https://doi.org/10.3389/fnut.2023.1166929

AUTHORS

7 · 8 CENTRES

Fred Brouns, Annelotte Van Haaps, Daniel Keszthelyi, Koen Venema, Marlies Bongers, Jacques Maas, Velja Mijatovic

1Department of Human Biology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands
2Endometriosis Center, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, Netherlands
3Amsterdam Reproduction and Development Research Institute, Amsterdam, Netherlands
4Division of Gastroenterology-Hepatology, Department of Internal Medicine, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands
5Centre for Healthy Eating & Food Innovation (HEFI), Maastricht University, Maastricht, Netherlands
6Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, Netherlands
7Grow-School of Oncology and Reproduction, Maastricht University, Maastricht, Netherlands
8Department of Obstetrics and Gynaecology MUMC+, Maastricht, Netherlands