Dietary B vitamins and glioma: A case–control study based on Chinese population
Frontiers in Nutrition · 9 authors, 1 centre
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This case-control study of 506 glioma cases and 506 matched controls in China found that higher dietary intake of five B vitamins (thiamine, riboflavin, nicotinic acid, folate, and biotin) was significantly associated with a decreased risk of glioma.
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Dietary intake of five B vitamins was assessed using a food frequency questionnaire, and the association with glioma risk was examined using logistic regression and restricted cubic spline models. After adjusting for confounding factors, the highest tertile of intake for thiamine (OR=0.09), riboflavin (OR=0.12), nicotinic acid (OR=0.24), folate (OR=0.07), and biotin (OR=0.14) was associated with a significantly decreased risk of glioma compared to the lowest tertile. The study also found significant dose-response relationships between B vitamin intake and glioma risk, with some vitamins showing nonlinear associations. The authors note that the effects of some vitamins, like thiamine and biotin, varied by glioma pathological type and grade.
