SEARCHNARRATIVE_REVIEWobstetrics and gynecology, cardiology

narrative_review·obstetrics and gynecology, cardiology, nutrition, clinical nutrition, preclinical research·PMC10264292

Dietary supplements and vascular function in hypertensive disorders of pregnancy

Pflugers Archiv · 4 authors, 1 centre

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review summarizes evidence on dietary supplements for preventing or reducing the risk of hypertensive disorders like preeclampsia by targeting placental vascular dysfunction. It concludes that while some supplements show potential, high heterogeneity and multifactorial pathogenesis limit definitive conclusions.

Full summary

808 CHARS

This narrative review discusses the pathophysiology of pregnancy-associated hypertensive disorders from a vascular perspective, highlighting placental ischemia and endothelial dysfunction. It evaluates several dietary supplements studied for their potential to prevent or reduce preeclampsia risk by targeting placental vascular development and function. The review summarizes findings from clinical trials and meta-analyses but notes significant limitations, including high study heterogeneity and the difficulty in distinguishing cause from effect between nutrient deficiencies and preeclampsia. It concludes that the role of dietary supplements has not been adequately studied and calls for future research using novel animal models and exploring effects on maternal, fetal, and offspring health outcomes.

STUDY TYPE

narrative_review

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10264292

Dietary supplements and vascular function in hypertensive disorders of pregnancy

Pflugers Archiv

READ THE FULL PAPER

ABSTRACT

Hypertensive disorders of pregnancy are complications that can lead to maternal and infant mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as hypertension and may be accompanied by other end organ damages including proteinuria, maternal organ disturbances including renal insufficiency, neurological complications, thrombocytopenia, impaired liver function, or uteroplacental dysfunction such as fetal growth restriction and stillbirth. Although the causes of these hypertensive disorders of pregnancy are multifactorial and elusive, they seem to share some common vascular-related mechanisms, including diseased spiral arteries, placental ischemia, and endothelial dysfunction. Recently, preeclampsia is being considered as a vascular disorder. Unfortunately, due to the complex etiology of preeclampsia and safety concerns on drug usage during pregnancy, there is still no effective pharmacological treatments available for preeclampsia yet. An emerging area of interest in this research field is the potential beneficial effects of dietary intervention on reducing the risk of preeclampsia. Recent studies have been focused on the association between deficiencies or excesses of some nutrients and complications during pregnancy, fetal growth and development, and later risk of cardiovascular and metabolic diseases in the offspring. In this review, we discuss the involvement of placental vascular dysfunction in preeclampsia. We summarize the current understanding of the association between abnormal placentation and preeclampsia in a vascular perspective. Finally, we evaluate several studied dietary supplementations to prevent and reduce the risk of preeclampsia, targeting placental vascular development and function, leading to improved pregnancy and postnatal outcomes.

CITATION EXPORT

Andy W C Man, Yawen Zhou, Ning Xia et al.. Dietary supplements and vascular function in hypertensive disorders of pregnancy. Pflugers Archiv. (2023). https://doi.org/10.1007/s00424-023-02810-2

AUTHORS

4 · 1 CENTRES

Andy W C Man, Yawen Zhou, Ning Xia, Huige Li

grid.410607.4Department of Pharmacology, Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131 Mainz, Germany