Journal of Applied Research in Intellectual Disabilities · 6 authors, 6 centres
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This randomized, triple-blind, placebo-controlled crossover trial tested whether daily multivitamin, mineral, and omega-3 fatty acid supplementation reduces aggressive incidents in individuals with intellectual disabilities. The study found no significant difference in aggressive incidents between the supplement and placebo groups.
The primary outcome, the mean number of aggressive incidents per day measured by the MOAS, showed no significant difference between groups, with a rate ratio of 0.93 (95% CI: 0.59–1.46). Secondary outcomes, including changes in quality of life and aggressive behaviour scores, also showed no significant differences. The number of adverse events was similar between groups. A key contextual factor was that 29.2% of the trial, including all crossover participants, occurred during the COVID-19 pandemic, which was associated with a doubling of aggressive incidents and a non-significant trend toward a reversal in the direction of the supplement's effect. Limitations include the potential confounding influence of the pandemic, a high proportion of participants using psychotropic medication (58.4%), and the generalizability of aggression measurement across different levels of intellectual disability.
