Journal of Cellular and Molecular Medicine · 6 authors, 8 centres
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This prospective non-randomized study compared changes in tear film total antioxidant capacity (TAC) and ascorbic acid (AA) after two refractive surgeries. The central result was that LALEX surgery resulted in a significantly smaller reduction in AA compared to FS-LASIK, especially in patients with dry eye disease.
A prospective non-randomized study compared post-operative tear film antioxidant levels in 33 eyes undergoing FS-LASIK and 75 eyes undergoing LALEX. The study found a significant reduction in AA one month after both procedures, but the decrement was significantly larger in the FS-LASIK group (p=0.0002). No significant overall change in TAC was observed between the groups. Subgroup analysis showed that patients with dry eye disease (DED) had a lower decrement in both TAC (p=0.0424) and AA (p=0.0043) after LALEX compared to FS-LASIK. Patients with high myopia also had a significantly lower AA decrement after LALEX (p=0.0165). The study is limited by its small sample size, 1-month follow-up duration, and collection of antioxidants from the tear film rather than directly from the corneal stroma.
