Antioxidants · 6 authors, 5 centres
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This randomized controlled trial subanalysis compared three very-low-volume exercise modalities in patients with metabolic syndrome. The central result was that only high-intensity interval training significantly increased telomere length and improved inflammatory markers, while strength-based exercises did not.
This study was a subanalysis of two randomized controlled trials investigating the effects of three very-low-volume exercise modalities in 167 obese metabolic syndrome patients over 12 weeks. Patients were assigned to LV-HIIT, one-set resistance training (1-RT), whole-body electromyostimulation (WB-EMS), or a control group receiving standard nutritional counseling. The primary finding was that only the LV-HIIT group showed a significant increase in telomere length (T/S ratio, p < 0.001). Concurrently, only LV-HIIT significantly reduced OS-related inflammatory markers (CRP, IL-6, LBP, all p < 0.05). All groups reduced body weight, but MetS severity improved only with LV-HIIT (p < 0.001) and 1-RT (p = 0.014). The study is limited by its subanalysis design, a final sample of 123 patients, and a 12-week duration. The results suggest that very-low-volume cardiovascular-based exercise may uniquely benefit telomere health and inflammation in this clinical population.
