Frontiers in dental medicine · 3 authors, 1 centre
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This narrative review synthesizes preclinical evidence from mouse and cell culture studies showing that discoidin domain receptors DDR1 and DDR2 are crucial for skeletal development and metabolism, with DDR2 having a particularly prominent role in early bone formation and regeneration.
This narrative review summarizes preclinical research on the roles of discoidin domain receptors (DDR1 and DDR2) in bone biology, drawing from conditional knockout mouse models, cell line experiments, and in vivo animal studies. The review details how DDR1 and DDR2 function in bone development and metabolism, with DDR1 influencing endochondral ossification and cortical bone properties when inactivated in chondrocytes or osteoblasts. DDR2 is highlighted as essential for early skeletal progenitor cell function and chondrogenesis, with its inactivation leading to dwarfism, reduced trabecular bone volume, and craniofacial defects. The review also discusses potential roles for DDR2 in suppressing osteoclastogenesis based on myeloid-lineage knockout models. The implications suggest DDRs as potential therapeutic targets for bone disorders.
