It found that while both groups showed sleep fragmentation and disordered breathing, KS patients had a specific reduction in REM sleep proportion, which was associated with episodic memory impairment.
Journal of Clinical Medicine · 13 authors, 7 centres
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It found that while both groups showed sleep fragmentation and disordered breathing, KS patients had a specific reduction in REM sleep proportion, which was associated with episodic memory impairment.
Both groups exhibited high prevalence of sleep-disordered breathing (82% of AUD, 71% of KS patients) and sleep fragmentation (increased stage shifts). A key specific finding was a lower proportion of REM sleep in KS patients compared to AUD patients and healthy controls. The study also noted that AUD patients had a lower proportion of slow-wave sleep, while this sleep stage was relatively preserved in KS patients. The authors hypothesize that REM sleep alterations in KS may relate to thiamine deficiency effects on the cholinergic system. Limitations include the relatively small sample size for the KS group and the potential confounding effects of long-term psychotropic medication use in some patients.