Drug delivery methods based on nanotechnology for the treatment of eye diseases

Annals of Medicine and Surgery · 7 authors, 5 centres

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TL;DR

This review highlights nanotechnology-based drug delivery systems, such as nanoparticles and liposomes, for ocular diseases.

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This review article synthesizes literature on nanotechnology-based drug delivery systems for ocular diseases, focusing on anterior segment conditions. Methods include evaluating various nanocarriers like liposomes, nanoparticles, and nanoemulsions for their formulation, characterization, and preclinical testing. Central results indicate that nanocarriers can offer advantages over conventional therapies, such as increased drug bioavailability, sustained release, and targeted delivery. Limitations noted include a general lack of comprehensive safety and toxicity data for many systems and the need for further research on stability and biocompatibility.

STUDY TYPE

other

SPECIALTY

ophthalmology

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100% · A

ORIGINAL PAPER

PMC10718325

Drug delivery methods based on nanotechnology for the treatment of eye diseases

Annals of Medicine and Surgery

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ABSTRACT

One of the most difficult tasks among the numerous medication delivery methods is ocular drug delivery. Despite having effective medications for treating ocular illness, we have not yet managed to develop an appropriate drug delivery strategy with the fewest side effects. Nanotechnology has the potential to significantly address the drawbacks of current ocular delivery systems, such as their insufficient therapeutic effectiveness and unfavourable side effects from invasive surgery or systemic exposure. The objective of the current research is to highlight and update the most recent developments in nano-based technologies for the detection and treatment of ocular diseases. Even if more work has to be done, the advancements shown here might lead to brand-new, very practical ocular nanomedicines.

CITATION EXPORT

Mohammed Tayeb Oucif Khaled, Abdelmalekd Zaater, Ilham Ben Amor et al.. Drug delivery methods based on nanotechnology for the treatment of eye diseases. Annals of Medicine and Surgery. (2023). https://doi.org/10.1097/MS9.0000000000001399

AUTHORS

7 · 5 CENTRES

Mohammed Tayeb Oucif Khaled, Abdelmalekd Zaater, Ilham Ben Amor, Soumeia Zeghoud, Asma Ben Amor, Hadia Hemmami, Ali Alnazza Alhamad

aDepartment of Process Engineering and Petrochemical, Faculty of Technology, University of El Oued, El Oued, Algeria
bRenewable Energy Development unit in Arid Zones (UDERZA), University of El Oued, El Oued, Algeria
cDepartment of Agronomy, Faculty of Nature and Life Sciences, University of El Oued, El Oued, Algeria
dBiodiversity laboratory and application of biotechnology in agriculture, University of El Oued, El Oued, Algeria
eDepartment of Chemistry, Faculty of Science, University of Aleppo, Aleppo, Syrian Arab Republic