Dynapenic abdominal obesity and incident multimorbidity: findings from the English longitudinal study on ageing

Aging Clinical and Experimental Research · 9 authors, 6 centres

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TL;DR

DAO was defined as waist circumference >102 cm in men and >88 cm in women, along with dynapenia (handgrip strength <27 kg for men and <16 kg for women).

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DAO was defined as waist circumference >102 cm in men and >88 cm in women, along with dynapenia (handgrip strength <27 kg for men and <16 kg for women). The study's limitations include reliance on self-reported conditions, the inability to account for medication use, and the predominantly Caucasian study population, which may limit generalizability.

STUDY TYPE

cohort

SPECIALTY

epidemiology

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ORIGINAL PAPER

PMC10363082

Dynapenic abdominal obesity and incident multimorbidity: findings from the English longitudinal study on ageing

Aging Clinical and Experimental Research

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ABSTRACT

Background Dynapenic abdominal obesity (DAO) (i.e., impairment in muscle strength and high waist circumference) is gaining interest, as it is associated with several important adverse health outcomes. However, the association between DAO and multimorbidity is largely unclear. Thus, the aim of the present study was to investigate the association between DAO at baseline and new onset multimorbidity over ten years of follow-up. Methods People participating in the English Longitudinal Study of Ageing were included. DAO was defined as waist circumference > 102 cm in men and > 88 cm in women, and a concomitant presence of dynapenia (handgrip strength defined as < 27 kg for men and < 16 kg for women). Multimorbidity was defined as having two or more chronic conditions. The association between DAO and incident multimorbidity was assessed using a multivariable logistic regression analysis, reporting the data as odds ratios (ORs) and their 95% confidence intervals (CIs). Results Overall, 3302 participants (mean age: 63.4 years, males: 50.3%) without multimorbidity at baseline were followed-up for ten years. After adjusting for several variables, compared to participants without dynapenia nor abdominal obesity, the presence of abdominal obesity (OR = 1.505; 95%CI: 1.272–1.780; p < 0.0001) and DAO (OR = 1.671; 95%CI: 1.201–2.325; p = 0.002) significantly increased the risk of multimorbidity. Compared to no dynapenia nor abdominal obesity, DAO was associated with significantly higher risk for arthritis and diabetes. Conclusions DAO was significantly associated with a higher risk of incident multimorbidity, over 10 years of follow-up. The results of our study suggest that addressing DAO can potentially decrease risk for multimorbidity.

CITATION EXPORT

Nicola Veronese, Ai Koyanagi, Pinar Soysal et al.. Dynapenic abdominal obesity and incident multimorbidity: findings from the English longitudinal study on ageing. Aging Clinical and Experimental Research. (2023). https://doi.org/10.1007/s40520-023-02455-2

AUTHORS

9 · 6 CENTRES

Nicola Veronese, Ai Koyanagi, Pinar Soysal, Vitalba Sapienza, Francesco Saverio Ragusa, Francesco Bolzetta, Ligia J. Dominguez, Mario Barbagallo, Lee Smith

1grid.10776.370000 0004 1762 5517Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Via del Vespro, 141, 90127 Palermo, Italy
2grid.466982.70000 0004 1771 0789Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAMISCIIIICREA, Pg. Lluis Companys 23, 08010 Barcelona, Spain
3grid.411675.00000 0004 0490 4867Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
4Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, Dolo-Mirano District, Dolo, Venice, Italy
5grid.440863.d0000 0004 0460 360XFaculty of Medicine and Surgery, Kore University of Enna, 94100 Enna, Italy
6grid.5115.00000 0001 2299 5510Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK