Biomedicines · 5 authors, 3 centres
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This preclinical animal study evaluated calcitriol and VDRM2 effects on soleus muscle regeneration in male Wistar rats after blunt injury. By day 14 post-injury, calcitriol-treated rats showed significantly greater incomplete tetanic force recovery and myofiber width compared to controls, while VDRM2 exhibited substantially lower biological activity.
This preclinical study investigated the effects of calcitriol and vitamin D Receptor Modulator 2 (VDRM2) on skeletal muscle regeneration in male Wistar rats following open blunt soleus muscle injury. Rats received local injections of calcitriol, VDRM2, or 10% ethanol (control) during the first four days after trauma. Muscle strength significantly decreased post-injury across all groups with gradual improvement, though full recovery was not achieved. By day 14, calcitriol-treated rats demonstrated significantly higher incomplete tetanic force compared to controls, with VDRM2-treated animals showing intermediate values. Histological analysis confirmed greater myofiber width in the calcitriol group. On day 4, calcitriol-treated animals exhibited increased cellular turnover with elevated proliferation and reduced apoptosis, while VDRM2 showed only increased proliferative activity. No significant differences were found between groups for CAE-positive cells or visible muscle tissue area. Limitations include the inability to directly extrapolate findings to humans and the use of longitudinal rather than cross-sectional histological analysis.
