Chinese Medical Journal · 9 authors, 2 centres
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This randomized controlled trial of 70 patients undergoing laparoscopic liver resection compared IVC respiratory variability-guided fluid therapy with standard fluid management in the anesthesia intensive care unit. The intervention group had a shorter time to first flatus and lower C-reactive protein at 24 hours postoperatively, but no significant differences in other short-term prognostic outcomes.
This single-center randomized controlled trial enrolled 70 patients undergoing laparoscopic liver resection between January 2018 and December 2019. Patients were randomized to either IVC respiratory variability-guided fluid therapy or standard fluid management in the anesthesia intensive care unit postoperatively. The primary outcome was time to flatus after surgery. The intervention group had a significantly shorter time to first flatus (1.5 ± 0.6 days vs. 2.0 ± 0.8 days) and lower CRP at 24 hours postoperatively (21.4 [95% CI: 11.9–36.7] mg/L vs. 44.8 [95% CI: 26.9–63.1] mg/L) compared with controls. No significant differences were found in time to defecation, serum D-lactic acid, MDA, renal function, severe postoperative complications, or length of stay. The authors concluded that IVC-guided fluid therapy facilitated bowel recovery but had negligible effects on overall short-term prognosis.
