JAMA Network Open · 10 authors, 6 centres
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This randomized clinical trial compared a remote mind-body skills training program to a health education program for adults with neurofibromatosis. Both programs improved quality of life immediately after treatment, but only the mind-body program's benefits were sustained and clinically significant at 12-month follow-up.
This randomized clinical trial enrolled 228 adults with neurofibromatosis to compare a remote mind-body skills training program (3RP-NF) to a health education program (HEP-NF). Both groups showed statistically significant and some clinically meaningful improvements in physical and psychological quality of life immediately post-treatment. However, by 12 months, improvements in the HEP-NF group had diminished, while improvements in the 3RP-NF group were sustained or increased, leading to statistically significant between-group differences favoring the 3RP-NF for physical health QOL and durability of effect for psychological QOL. The study's population was predominantly White, educated women, which may limit generalizability. The findings suggest the mind-body program provides durable quality of life benefits beyond those of health education alone for this population.
