SEARCHCOHORTobstetrics and gynecology, psychiatry

cohort·obstetrics and gynecology, psychiatry, pediatrics, epidemiology, public health·PMC10544486

Effect of nausea and vomiting during pregnancy on mother-to-infant bonding and the mediation effect of postpartum depression: the Japan Environment and Children’s Study

BMC Pregnancy and Childbirth · 6 authors, 4 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

However, NVP also increased the risk of postpartum depression, which in turn inhibited MIB development.

Full summary

725 CHARS

This study analyzed data from the Japan Environment and Children’s Study, a nationwide prospective birth cohort of 87,658 mothers. Postpartum depression was assessed with the Edinburgh Postpartum Depression Scale (EPDS). The key finding from logistic regression was that mothers with Moderate NVP (adjusted OR 0.93) and Severe NVP (adjusted OR 0.81) had a reduced risk of MIB disorder compared to those with no NVP. Mediation analysis revealed a dual effect: NVP had a direct, negative association with MIBS-J scores (indicating better bonding), particularly for Severe NVP (β: -0.091). The findings suggest that while NVP may have a direct bonding-promoting effect, this is counteracted by its link to postpartum depression.

STUDY TYPE

cohort

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10544486

Effect of nausea and vomiting during pregnancy on mother-to-infant bonding and the mediation effect of postpartum depression: the Japan Environment and Children’s Study

BMC Pregnancy and Childbirth

READ THE FULL PAPER

ABSTRACT

Abstract Background Mother-to-infant bonding (MIB) is critical for the health and well-being of the mother and child. Furthermore, MIB has been shown to boost the social-emotional development of infants, while also giving mothers a sense of happiness in raising their children. Nausea and vomiting during pregnancy (NVP) is a normal complication of pregnancy, occurring in approximately 50–90% of pregnant women in the early stages of pregnancy. Despite widespread knowledge of MIB and postpartum depression, little research attention has been given to the effects of NVP on MIB. This study aimed to investigate the relationship between NVP and MIB and the mediating effects of postpartum depression. Methods We analyzed the data of 88,424 infants and 87,658 mothers from the Japan Environment and Children’s Study (JECS), which is a government-funded nationwide birth prospective cohort study. The Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) was used to assess MIB, and the Edinburgh Postpartum Depression Scale (EPDS) was utilized to assess postpartum depression. We divided participants into four groups according to a self-reported questionnaire assessing NVP (No NVP, Mild NVP, Moderate NVP, and Severe NVP). MIB disorder was defined as a MIBS-J score ≥ 5. Logistic analysis was performed to evaluate the effect of NVP on MIB disorder at one year after delivery. A mediation analysis was conducted to examine whether postpartum depression mediated the association between NVP and MIBS-J scores. Results The logistic regression analysis results revealed reduced risks of MIB disorder among mothers with Moderate NVP (adjusted OR 0.93; 95% confidence interval, 0.86–0.99) and Severe NVP (adjusted OR 0.81; 95% confidence interval, 0.74–0.89), compared to those with No NVP. The mediation analysis revealed that NVP positively correlated with MIBS-J score in the indirect effect via postpartum depression, while NVP (Mild NVP, Moderate NVP, and Severe NVP) negatively correlated with MIBS-J score in the direct effect. Conclusion The risks of MIB disorder were reduced in the Moderate NVP and Severe NVP mothers, although NVP inhibited the development of MIB via postpartum depression. The development of effective interventions for postpartum depression is important to improve MIB among mothers with NVP. Keywords: Nausea and vomiting during pregnancy, Mother-to-infant bonding, Postpartum depression, Birth cohort

CITATION EXPORT

Gui Yang, Aya Hisada, Midori Yamamoto et al.. Effect of nausea and vomiting during pregnancy on mother-to-infant bonding and the mediation effect of postpartum depression: the Japan Environment and Children’s Study. BMC Pregnancy and Childbirth. (2023). https://doi.org/10.1186/s12884-023-06014-5

AUTHORS

6 · 4 CENTRES

Gui Yang, Aya Hisada, Midori Yamamoto, Akiko Kawanami, Chisato Mori, Kenichi Sakurai

1Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoicho, Inageku, Chiba Japan
2Department of Sustainable Health Science, Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoicho, Inageku, Chiba Japan
3Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba Japan
4Department of Occupational and Environmental Health, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-Cho, Mizuho-Ku, Nagoya, Japan