SEARCHNARRATIVE_REVIEWobstetrics and gynecology, endocrinology

narrative_review·obstetrics and gynecology, endocrinology, nutrition, preclinical research·PMC10294056

Effect of resveratrol in gestational diabetes mellitus and its complications

World Journal of Diabetes · 7 authors, 7 centres

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TL;DR

The central result is that resveratrol shows promise in modulating pathways involved in glucose metabolism, oxidative stress, and placentation in these models.

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The review suggests resveratrol may improve GDM indicators by influencing glucose metabolism, insulin tolerance, and oxidative stress through pathways like AMPK and SIRT1. It also highlights potential to ameliorate complications such as impaired placentation and embryonic development defects.

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narrative_review

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obstetrics and gynecology

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ORIGINAL PAPER

PMC10294056

Effect of resveratrol in gestational diabetes mellitus and its complications

World Journal of Diabetes

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ABSTRACT

Abstract The incidence rate of diabetes in pregnancy is about 20%, and diabetes in pregnancy will have a long-term impact on the metabolic health of mothers and their offspring. Mothers may have elevated blood glucose, which may lead to blood pressure disease, kidney disease, decreased resistance and secondary infection during pregnancy. The offspring may suffer from abnormal embryonic development, intrauterine growth restriction, obesity, autism, and other adverse consequences. Resveratrol (RSV) is a natural polyphenol compound, which is found in more than 70 plant species and their products, such as Polygonum cuspidatum , seeds of grapes, peanuts, blueberries, bilberries, and cranberries. Previous studies have shown that RSV has a potential beneficial effect on complex pregnancy, including improving the indicators of diabetes and pregnancy diabetes syndrome. This article has reviewed the molecular targets and signaling pathways of RSV, including AMP-activated protein kinase, mitogen-activated protein kinases, silent information regulator sirtuin 1, miR-23a-3p, reactive oxygen species, potassium channels and CX3C chemokine ligand 1, and the effect of RSV on gestational diabetes mellitus (GDM) and its complications. RSV improves the indicators of GDM by improving glucose metabolism and insulin tolerance, regulating blood lipids and plasma adipokines, and modulating embryonic oxidative stress and apoptosis. Furthermore, RSV can ameliorate the GDM complications by reducing oxidative stress, reducing the effects on placentation, reducing the adverse effects on embryonic development, reducing offspring's healthy risk, and so on. Thus, this review is of great significance for providing more options and possibilities for further research on medication of gestational diabetes. Keywords: Gestational diabetes mellitus, Complication, Resveratrol, Polyphenol, Pathway

CITATION EXPORT

Hui-Zhong Ma, Yuan Chen, Hao-Hao Guo et al.. Effect of resveratrol in gestational diabetes mellitus and its complications. World Journal of Diabetes. (2023). https://doi.org/10.4239/wjd.v14.i6.808

AUTHORS

7 · 7 CENTRES

Hui-Zhong Ma, Yuan Chen, Hao-Hao Guo, Jing Wang, Xiu-Lan Xin, Yan-Cheng Li, Yu-Feng Liu

1School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, Liaoning Province, China
2School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, Liaoning Province, China
3School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, Liaoning Province, China
4School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, Liaoning Province, China
5College of Bioengineering, Beijing Polytechnic, Beijing 100176, China
6Department of Epidemiology, University of Florida, Gainesville, FL 32608, United States
7School of Pharmaceutical Sciences, Natural Products Pharmaceutical Engineering Technology Research Center of Liaoning Province, Liaoning University, Shenyang 110036, Liaoning Province, China. [email protected]