Current Issues in Molecular Biology · 11 authors, 8 centres
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This study evaluated the reproductive toxicity of an aqueous extract from Chrysobalanus icaco leaves in pregnant Wistar rats. The central result was that the extract, at doses up to 400 mg/kg, did not cause maternal systemic toxicity or adverse effects on reproductive outcomes or fetal development.
This preclinical study investigated the reproductive toxicity of an aqueous extract from Chrysobalanus icaco leaves (AECi) in pregnant Wistar rats. The extract was administered orally at doses of 100, 200, and 400 mg/kg during the periods of embryogenesis and organogenesis. Researchers assessed maternal systemic toxicity by monitoring behavior, food/water consumption, and body/organ weights. Reproductive outcomes included the number of corpora lutea and implantation sites. Fetal development was evaluated through fetal weight, placental weight and morphology, and the presence of skeletal or visceral malformations. The study found no signs of maternal toxicity, and the extract did not affect reproductive parameters or cause fetal malformations, except for a reduction in placental disc area in the highest dose group. The authors concluded that, under these experimental conditions, AECi did not induce reproductive toxicity. Limitations include that the findings are specific to a rat model and the mechanisms behind the placental morphometric change require further investigation.
