SEARCHRCTobstetrics and gynecology, psychiatry

RCT·obstetrics and gynecology, psychiatry, nutrition, clinical trial, public health·PMC10381046

Effect of the INTER-ACT lifestyle intervention on maternal mental health during the first year after childbirth: A randomized controlled trial

PLOS ONE · 7 authors, 10 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This randomized controlled trial found that the INTER-ACT postpartum lifestyle intervention was associated with improvements in depressive symptoms and sense of coherence, but these effects differed depending on a woman's pre-pregnancy BMI category.

Full summary

981 CHARS

This multicentre randomized controlled trial assessed the INTER-ACT postpartum lifestyle intervention in 1047 women (542 intervention, 505 control) to determine its effect on mental health outcomes during the first year after childbirth. The intervention comprised coaching sessions and an e-health app. Mixed models revealed no difference between arms for anxiety or quality of life. However, the intervention showed an improvement in depressive symptoms and sense of coherence, but this depended on pre-pregnancy BMI. Women with normal/overweight pre-pregnancy BMI in the intervention arm showed a decrease in depressive symptoms, while women with pre-pregnancy obesity showed a smaller increase. The discussion notes the intervention's focus on weight may have had an initial adverse effect on mood in women with obesity. Limitations include potential lack of statistical power for mental health outcomes and that the control arm may have been influenced by regular home visits.

STUDY TYPE

RCT

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10381046

Effect of the INTER-ACT lifestyle intervention on maternal mental health during the first year after childbirth: A randomized controlled trial

PLOS ONE

READ THE FULL PAPER

ABSTRACT

We assess whether the INTER-ACT postpartum lifestyle intervention influences symptoms of depression and anxiety, sense of coherence and quality of life during the first year after childbirth. A total of 1047 women of the INTER-ACT RCT were randomized into the intervention (n = 542) or control arm (n = 505). The lifestyle intervention consisted of 4 face-to-face coaching sessions, supported by an e-health app. Anthropometric and mental health data were collected at baseline, end of intervention and 6-months follow-up. We applied mixed models to assess whether the evolution over time of depressive symptoms, anxiety, sense of coherence and quality of life differed between the intervention and control arm, taking into account the women’s pre-pregnancy BMI. There was no statistical evidence for a difference in evolution in anxiety or quality of life between intervention and control arm. But an improvement in symptoms of depression and sense of coherence was observed in women who received the intervention, depending on the mother’s pre-pregnancy BMI. Women with normal/overweight pre-pregnancy BMI, reported a decrease in EPDS between baseline and end of intervention, and the decrease was larger in the intervention arm (control arm: -0.42 (95% CI, -0.76 to -0.08); intervention arm: -0.71 (95% CI, -1.07 to -0.35)). Women with pre-pregnancy obesity showed an increase in EPDS between baseline and end of intervention, but the increase was less pronounced in the intervention arm (control arm: +0.71 (95% CI, -0.12 to 1.54); intervention arm: +0.42 (95% CI -0.42 to 1.25)). Women with a normal or obese pre-pregnancy BMI in the intervention arm showed a decrease in sense of coherence between baseline and end of intervention (-0.36) (95% CI, -1.60 to 0.88), while women with overweight pre-pregnancy showed an increase in sense of coherence (+1.53) (95% CI, -0.08 to 3.15) between baseline and end of intervention. Receiving the INTER-ACT postpartum lifestyle intervention showed improvement in depressive symptoms, in normal weight or overweight women on the short run, as well as improvement in sense of coherence in women with pre-pregnancy overweight only. Trial registration: ClinicalTrials.gov; NCT02989142 .

CITATION EXPORT

Hanne Van Uytsel, Lieveke Ameye, Roland Devlieger et al.. Effect of the INTER-ACT lifestyle intervention on maternal mental health during the first year after childbirth: A randomized controlled trial. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0284770

AUTHORS

7 · 10 CENTRES

Hanne Van Uytsel, Lieveke Ameye, Roland Devlieger, Margriet Bijlholt, Katleen Van der Gucht, Yves Jacquemyn, Annick Bogaerts

1 REALIFE research group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
2 Department of Obstetrics and Gynecology, University Hospital Leuven, Leuven, Belgium
3 Department of Obstetrics and Gynecology, GZA Hospitals Sint- Augustinus, Antwerp, Belgium
4 Centre for Research and Innovation in Care (CRIC), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
5 Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium
6 Leuven Mindfulness Centre, KU Leuven, Leuven, Belgium
7 Department of Obstetrics and Gynecology, University Hospital Antwerp, Antwerp, Belgium
8 Global Health Institute (GHI), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
9 Faculty of Health, University of Plymouth, Devon, United Kingdom
PhD, PLOS, UNITED KINGDOM

EDITOR / REVIEWER

Dario Ummarino