Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study

Scientific Reports · 9 authors, 2 centres

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TL;DR

A randomized, self-control clinical study evaluated a lotion containing VHProbi® Mix R probiotic ferment lysate in individuals with sensitive skin over 30 days. The lotion significantly reduced transepidermal water loss, redness, and improved skin moisturization, indicating enhanced skin barrier function.

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In vitro assays showed that fermented cultures of E06 and E12 exhibited DPPH radical scavenging activity and protected HaCaT keratinocyte cells from toxicity induced by S. aureus, hydrogen peroxide, and UVB radiation. Participants applied the lotion for 30 days. At day 30, TEWL significantly decreased (P < 0.01), skin moisturization significantly increased, and redness decreased significantly as measured by both CK®-MPA (P < 0.01) and VISIA®-CR. BoSS and self-assessment questionnaires indicated perceived improvement. Limitations include the absence of a placebo control group, potential placebo effects, no assessment of skin microbiota changes, and a short intervention duration. The authors acknowledge that rigorous evidence requires future randomized placebo-controlled trials.

STUDY TYPE

RCT

SPECIALTY

dermatology

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AI pipeline

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ORIGINAL PAPER

PMC10558477

Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study

Scientific Reports

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ABSTRACT

There is an emergent need to develop functional cosmetic ingredients for the topical management of skin barrier function. This study aimed to investigate the efficacy of a lotion containing fermented lysates VHProbi® Mix R for enhancing the skin barrier. In vitro studies demonstrated that fermented cultures of both Lacticaseibacillus rhamnosus VHProbi® E06 (E06) and L. paracasei VHProbi® E12 (E12) had antioxidant capacity, showing promising scavenging capability for 2,2-diphenyl-1-picryl-hydrazyl. The antioxidant capacity of these strains was also demonstrated in the model of Caenorhabditis elegans . In addition, the fermented lysates of both E06 and E12 enhanced the proliferation of HaCaT cells and ameliorated the toxicity induced by Staphylococcus aureus ATCC 25923, hydrogen peroxide, and ultraviolet B radiation in the HaCaT cell models, which simulated the irritants that facial sensitive skin is exposed to. Subsequently, the ingredient VHProbi® Mix R was formulated using four kinds of fermented lysates: E06, E12, Lactiplantibacillus plantarum VHProbi® E15, and Lactobacillus helveticus VHProbi® Y21. A clinical study was conducted to investigate whether a lotion containing VHProbi® Mix R would be beneficial for people to enhance skin barrier. The participants were asked to use the investigational product for 30 days. Several indicators, including transepidermal water loss (TEWL), skin moisturization, and redness were measured at day 0 and day 30 using VISIA®-CR and CK®-MPA systems. Meanwhile, the burden of sensitive skin (BoSS) and self-assessment questionnaires were performed at baseline and endpoint of this study. The study data showed that at day 30, there was a significant decrease in TEWL ( P < 0.01), redness measured by CK®-MPA ( P < 0.01), and redness profile measured by VISIA®-CR compared with the baseline measurements. Skin moisturization had significantly increased after treatment with the lotion for 30 days. BoSS and self-assessment questionnaires also substantiated that the participants felt a markedly positive change in their sensitive skin. Hence, we hypothesize that applying the topical functional VHProbi® Mix R could confer effective benefits for people with sensitive skin and this represents a promising intervention for enhancing skin barrier.

CITATION EXPORT

Hongchang Cui, Congrui Feng, Tao Zhang et al.. Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study. Scientific Reports. (2023). https://doi.org/10.1038/s41598-023-43336-y

AUTHORS

9 · 2 CENTRES

Hongchang Cui, Congrui Feng, Tao Zhang, Verónica Martínez-Ríos, Patricia Martorell, Marta Tortajada, Sidao Cheng, Shumin Cheng, Zhi Duan

1grid.518892.fQingdao Vland Biotech Co., Ltd., 596-1 Jiushui East Road, Laoshan District, Qingdao, 266102 China
2grid.432046.7ADM, Nutrition, Health and Wellness, Biopolis S.L., Parc Científic Universitat de València, C/ Catedrático Agustín Escardino Benlloch, 9, 46980 Paterna, Spain