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TL;DR
This narrative review evaluates how carotenoids, as antioxidants, may mitigate mitochondrial dysfunction and oxidative stress implicated in age-related diseases like Alzheimer's and diabetes.
Biochemical Society Transactions · 6 authors, 3 centres
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This narrative review evaluates how carotenoids, as antioxidants, may mitigate mitochondrial dysfunction and oxidative stress implicated in age-related diseases like Alzheimer's and diabetes.
This narrative review evaluates existing literature on the relationship between carotenoids, mitochondrial dysfunction, and oxidative stress. It discusses how reactive oxygen species (ROS) are produced during mitochondrial oxidative phosphorylation and how increased mitochondrial-derived ROS are linked to dysfunction, an early event in age-related diseases such as Alzheimer's disease and metabolic disorders like diabetes. The review posits that carotenoids, which have antioxidant capacities and can accumulate in mitochondria, may ameliorate mitochondrial dysfunction, though their exact role is not fully understood. It highlights that targeting mitochondrial metabolism and ROS is a promising approach for treating age-related diseases.