Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA)

Nutrients · 16 authors, 6 centres

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TL;DR

At 12 months, there was no statistically significant difference between groups for most quality of life domains, including urinary incontinence, sexual function, and bowel function.

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At 12 months, there was no statistically significant difference between groups for most quality of life domains, including urinary incontinence, sexual function, and bowel function.

STUDY TYPE

RCT

SPECIALTY

oncology

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AI pipeline

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ORIGINAL PAPER

PMC10052536

Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA)

Nutrients

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ABSTRACT

Abstract Prostate cancer (PCa) and associated treatments incur symptoms that may impact patients’ quality of life. Studies have shown beneficial relationships between diet, especially omega-3 fatty acids, and these symptoms. Unfortunately, only few data describing the relationship between long-chain omega-3 fatty acids (LCn3) and PCa-related symptoms in patients are available. The purpose of this study was to evaluate the effects of LCn3 supplementation on PCa-specific quality of life in 130 men treated by radical prostatectomy. Men were randomized to receive a daily dose of either 3.75 g of fish oil or a placebo starting 7 weeks before surgery and for up to one-year post-surgery. Quality of life was assessed using the validated EPIC-26 and IPSS questionnaires at randomization, at surgery, and every 3 months following surgery. Between-group differences were assessed using linear mixed models. Intention-to-treat analyses showed no significant difference between the two groups. However, at 12-month follow-up, per-protocol analyses showed a significantly greater increase in the urinary irritation function score (better urinary function) (MD = 5.5, p = 0.03) for the LCn3 group compared to placebo. These results suggest that LCn3 supplementation may improve the urinary irritation function in men with PCa treated by radical prostatectomy and support to conduct of larger-scale studies. Keywords: fish oil, eicosapentaenoic acid (EPA), prostate cancer, prostate-specific quality of life, surgery

CITATION EXPORT

Hanane Moussa, Karine Robitaille, Jean-François Pelletier et al.. Effects of Concentrated Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplementation on Quality of Life after Radical Prostatectomy: A Phase II Randomized Placebo-Controlled Trial (RCT-EPA). Nutrients. (2023). https://doi.org/10.3390/nu15061369

AUTHORS

16 · 6 CENTRES

Hanane Moussa, Karine Robitaille, Jean-François Pelletier, Roxane Tourigny, Yves Fradet, Louis Lacombe, Paul Toren, Michele Lodde, Rabi Tiguert, Thierry Dujardin, Yves Caumartin, Thierry Duchesne, Pierre Julien, Josée Savard, Caroline Diorio, Vincent Fradet

1CHU de Québec-Université Laval Research Center, Québec, QC G1R 3S1, Canada
2Institute of Nutrition and Functional Foods (INAF) and NUTRISS Center—Nutrition, Health and Society of Université Laval, Québec, QC G1V 0A6, Canada
3Centre de Recherche sur le Cancer de l’Université Laval, Québec, QC G1R 3S3, Canada
4Centre Intégré de Cancérologie du CHU de Québec-Université Laval, Québec, QC G1J 5B3, Canada
5Department of Mathematics and Statistics, Université Laval, Québec, QC G1V 0A6, Canada
6School of Psychology, Université Laval, Québec, QC G1V 0A6, Canada