Effects of Pine Pollen Polysaccharides and Sulfated Polysaccharides on Ulcerative Colitis and Gut Flora in Mice

Polymers · 5 authors, 1 centre

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TL;DR

This preclinical mouse study tested two forms of pine pollen polysaccharide, PPM60 and SPPM60, in a dextran sodium sulfate-induced colitis model. The central result was that both polysaccharides alleviated symptoms, reduced inflammation, and modulated gut flora and serum metabolism.

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This preclinical animal study investigated the effects of Pinus yunnanensis pollen polysaccharides (PPM60) and their sulfated derivative (SPPM60) on dextran sodium sulfate-induced ulcerative colitis in mice. Methods included evaluating intestinal cytokines, serum metabolomics, and gut flora composition. The results showed that both PPM60 and SPPM60 alleviated disease progression, as evidenced by improved weight loss, reduced colon shortening, and repaired intestinal injury. Immunologically, they increased anti-inflammatory cytokines (IL-2, IL-10, IL-13) and decreased pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). Serum metabolism analysis indicated PPM60 mainly regulated energy-related pathways, while SPPM60 regulated lipid-related pathways.

STUDY TYPE

other

SPECIALTY

gastroenterology

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10058757

Effects of Pine Pollen Polysaccharides and Sulfated Polysaccharides on Ulcerative Colitis and Gut Flora in Mice

Polymers

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ABSTRACT

Polysaccharides are important biological macromolecules in all organisms, and have recently been studied as therapeutic agents for ulcerative colitis (UC). However, the effects of Pinus yunnanensis pollen polysaccharides on ulcerative colitis remains unknown. In this study, dextran sodium sulfate (DSS) was used to induce the UC model to investigate the effects of Pinus yunnanensis pollen polysaccharides (PPM60) and sulfated polysaccharides (SPPM60) on UC. We evaluated the improvement of polysaccharides on UC by analyzing the levels of intestinal cytokines, serum metabolites and metabolic pathways, intestinal flora species diversity, and beneficial and harmful bacteria. The results show that purified PPM60 and its sulfated form SPPM60 effectively alleviated the disease progression of weight loss, colon shortening and intestinal injury in UC mice. On the intestinal immunity level, PPM60 and SPPM60 increased the levels of anti-inflammatory cytokines (IL-2, IL-10, and IL-13) and decreased the levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α). On the serum metabolism level, PPM60 and SPPM60 mainly regulated the abnormal serum metabolism of UC mice by regulating the energy-related and lipid-related metabolism pathways, respectively. On the intestinal flora level, PPM60 and SPPM60 reduced the abundance of harmful bacteria (such as Akkermansia and Aerococcus ) and induced the abundance of beneficial bacteria (such as lactobacillus ). In summary, this study is the first to evaluate the effects of PPM60 and SPPM60 on UC from the joint perspectives of intestinal immunity, serum metabolomics, and intestinal flora, which may provide an experimental basis for plant polysaccharides as an adjuvant clinical treatment of UC.

CITATION EXPORT

Yali Wang, Xiao Song, Zhanjiang Wang et al.. Effects of Pine Pollen Polysaccharides and Sulfated Polysaccharides on Ulcerative Colitis and Gut Flora in Mice. Polymers. (2023). https://doi.org/10.3390/polym15061414

AUTHORS

5 · 1 CENTRES

Yali Wang, Xiao Song, Zhanjiang Wang, Zhenxiang Li, Yue Geng

Key Laboratory of Food Nutrition and Safety of SDNU, Provincial Key Laboratory of Animal Resistant Biology, College of Life Science, Shandong Normal University, Jinan 250014, China

EDITOR / REVIEWER

Kit Leong Cheong, Saiyi Zhong